نتایج جستجو برای: chemoresistance

تعداد نتایج: 5112  

2016
Hong Ren Peizhun Du Zongyu Ge Yiting Jin Di Ding Xiuping Liu Qiang Zou

Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and BMI1 are up-regulated in various cancers and have a positive correlation with ...

Journal: :The EMBO journal 2006
Olivier E Pardo Claudia Wellbrock Umme K Khanzada Muriel Aubert Imanol Arozarena Sally Davidson Frances Bowen Peter J Parker V V Filonenko Ivan T Gout Neil Sebire Richard Marais Julian Downward Michael J Seckl

Patients with small cell lung cancer (SCLC) die because of chemoresistance. Fibroblast growth factor-2 (FGF-2) increases the expression of antiapoptotic proteins, XIAP and Bcl-X(L), and triggers chemoresistance in SCLC cells. Here we show that these effects are mediated through the formation of a specific multiprotein complex comprising B-Raf, PKCepsilon and S6K2. S6K1, Raf-1 and other PKC isof...

Journal: :Scientific Reports 2021

Abstract Taxane is a family of front-line chemotherapeutic agents against ovarian cancer (OC). The therapeutic efficacy frequently counteracted by the development chemoresistance, leading to high rates relapse in OC patients. role(s) microRNAs (miRNAs) chemoresistance had been supported many evidences Epigenetic regulation miRNAs has reported influence and response therapeutics, however, their ...

2014
Kevin Tak-Pan Ng Chung Mau Lo Dong Yong Guo Xiang Qi Chang Xian Li Wei Geng Xiao Bing Liu Chang Chun Ling Yuen Yuen Ma Wai Ho Yeung Yan Shao Ronnie Tung-Ping Poon Sheung Tat Fan Kwan Man

Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets in hepatocellular carcinoma, chemoresistant hepatocellular carcinoma cell lines were established. By comparing the global gene expression profiles between chemoresistant and chemosensitive cell lines...

Journal: :The Journal of biological chemistry 2010
Claudia R Oliva Susan E Nozell Anne Diers Samuel G McClugage Jann N Sarkaria James M Markert Victor M Darley-Usmar Shannon M Bailey G Yancey Gillespie Aimee Landar Corinne E Griguer

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of high-grade gliomas. Acquired chemoresistance is a severe limitation to this therapy with more than 90% of recurrent gliomas showing no response to a second cycle of chemotherapy. Efforts to better understand the underlying mechanisms of acquired chemoresistance to TMZ and potential strategies to overcome chemoresistance ar...

2017
Wen-Ting Chen Yu-Jia Yang Zhen-Dong Zhang Qiang An Na Li Wei Liu Bing Yang

BACKGROUND We aimed to investigate the function of miR-1307 in chemoresistance and to explore its chemoresistance mechanism in ovarian cancer. METHODS IC50 determination was used to test the chemoresistance profling in ovarian cancer cells. QRT-PCR or western blot was used to validate the expression level of miR-1307 and candidate gene or protein. Colony formation assay and FITC-labeled enhan...

2017
Akshay Malhotra Manju Jain Hridayesh Prakash Karen M. Vasquez Aklank Jain

Chemoresistance is one of the major hurdles in the treatment of breast cancer, which limits the effect of both targeted and conventional therapies in clinical settings. Therefore, understanding the mechanisms underpinning resistance is paramount for developing strategies to circumvent resistance in breast cancer patients. Several published reports have indicated that lncRNAs play a dynamic role...

2018
Shan Shan Li Jing Ma Alice S T Wong

Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains a therapeutic challenge. Thus, understanding the biology of chemoresistance is of great importance to overcome this challenge and will conceivably benefit the surviva...

Journal: :Molecular medicine reports 2012
Qing-Hua Liu Chen-Yan Zhao Jing Zhang Ying Chen Li Gao Can-Yong Ni Ming-Hua Zhu

The most notable obstacle hindering the effective treatment of human pancreatic cancer is intrinsic chemoresistance. In order to identify the candidate protein(s) responsible for the intrinsic chemoresistance, the protein expression profiling of human pancreatic adenocarcinoma cell line Capan-1 and its distinct surviving cells following primary tr...

Journal: :European journal of cancer 2014
Xiaoran Liu Xiaodong Tian Feng Wang Yongsu Ma Marko Kornmann Yinmo Yang

Gemcitabine is a standard chemotherapeutic agent for locally advanced and metastatic pancreatic cancer. However, the chemoresistance of pancreatic cancer is the major barrier to efficient chemotherapy. Here, we reported that BRG1, a chromatin modulator, was exclusively overexpressed in human pancreatic ductal adenocarcinoma tissues. BRG1 knockdown inhibited PANC-1 and MIA PaCa-2 cell growth in ...

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