Enhancers are closely positioned with actively transcribed target genes by chromatin looping. Non-coding RNAs are often transcribed on active enhancers, referred to as eRNAs (enhancer RNAs). To explore the kinetics of enhancer-promoter looping and eRNA transcription during transcriptional activation, we induced the β-globin locus by chemical treatment and analysed cross-linking frequency betwee...

Transdermal transport is now becoming one of the most convenient and safe pathways for drug delivery. In some cases it is necessary to use skin penetration enhancers in order to allow for the transdermal transport of drugs that are otherwise insufficiently skin-permeable. A series of oleanolic acid amides as potential transdermal penetration enhancers was formed by multistep synthesis and the s...

Now a day transdermal drug deliveries are increasing rapidly for the treatment of various diseases so the present study was conducted on different penetration enhancers for permeation of antidiabetic drug, glipizide (sulfonyl urea derivative) through skin. Different types of penetration enhancers such as terpenes and terpenoids, pyrrolidones, oxazolidinones, fatty acids etc are used for permeat...

lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. it has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. to overcome the poor bioavailability of the drug, transdermal patches have been prepared. the present study also aims at optimization of ...

The objective of the present study is to explore the efficient chemical penetration enhancer among the various enhancers available in overcoming the stratum corneum barrier in transdermal delivery of Alfuzosin hydrochloride (AH). The different enhancers were incorporated in 2% Carbopol gel which was selected as a control and evaluated by in vitro diffusion studies through dialysis membrane and ...

The chemical modification of histones at specific DNA regulatory elements is linked to the activation, inactivation and poising of genes. A number of tools exist to predict enhancers from chromatin modification maps, but their practical application is limited because they either (i) consider a smaller number of marks than those necessary to define the various enhancer classes or (ii) work with ...