The subcutaneous tissue of the hamster cheek pouch, a site of immunologic privilege, has been used to investigate the potential infectivity of different types of parasites. It has been demonstrated that the implantation of fragments of lesions induced by the fungus Lacazia loboi, the etiologic agent of Jorge Lobo's disease, into the subcutaneous tissue of the hamster cheek pouch resulted in par...

Interleukin-5 (IL-5) is a cytokine that preferentially effects the development and function of eosinophils, and is considered important in the pathophysiology of allergic inflammation. In this study, we evaluated the ability of recombinant human IL-5 (rHu IL-5) to promote tissue eosinophilia and the importance of this eosinophilia to pathological alterations in vascular function. Repetitive sub...

In this study, we investigated the effects of an Eriobotrya japonica seed extract (ESE) on mucositis using a 5-fluorouracil (5-FU)-induced mucositis hamster model. This model was prepared by intraperitoneally administering 90 mg/kg of 5-FU to hamsters on Day 1, scratching 1 cm(2) of the left cheek pouch of hamsters with a wire brush on Days 2, 3, and 4, and intraperitoneally administering 60 mg...

The goal of this study was to determine whether cigarette smoke extract alters dilatation of arterioles in vivo in response to agonists that produce activation of ATP-sensitive potassium channels and activation of adenylate cyclase. By using intravital microscopy, we measured diameter of arterioles contained within the microcirculation of the hamster cheek pouch during suffusion with agonists i...

Despite extensive investigations of the pulmonary circulation using both in vitro and in vitro preparations, few direct microcirculatory studies have been made. Consequently, the mechanisms involved in the response of the pulmonary microvasculature to changes in oxygen tension remain unclear. The present study represents the first direct observation of the responses in pulmonary microvessels to...

2 Present address : Department of Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York. Received for publication November 20, 1964. i.m. sites, even though primary implants grew in the latter 3 sites for 1—3weeks. This observation supports the con cept that the hamster pouch is an immunologically privi leged site similar to the anterior chamber of the eye and the brain (5, 6). T...

The studies demonstrated that the use of dimethyl sulfoxide (DMSO) as a vehicle for dimethylbenzanthracene in the produc tion of experimental tumors in the hamster cheek pouch, sig nificantly reduced the latent period for tumor production when compared to the usual mineral oil vehicle. No systemic or local changes could be attributed to the DMSO itself, and the mor phology of induced tumors was...

the necessary operative procedures and by the physical confines of the chamber. The advantages realized by using the mem branous cheek pouch of the hamster as a site for transplantation are (a) the tumor grows freely without physical hindrance and in a normal physi ological environment; (b) the same tumor can be observed at successive stages (measured, photo graphed) ; (c) the tumor may be subj...

The studies demonstrated that the use of dimethyl sulfoxide (DMSO) as a vehicle for dimethylbenzanthracene in the produc tion of experimental tumors in the hamster cheek pouch, sig nificantly reduced the latent period for tumor production when compared to the usual mineral oil vehicle. No systemic or local changes could be attributed to the DMSO itself, and the mor phology of induced tumors was...

A series of transplant·explant experiments using the H 4-II-E rat hepatoma cell line and golden hamsters have been carried out. Tissue culture cells implanted into the cheek pouch of hydrocortisone treated hamsters at a concentration of 106 cells per pouch produced tumors which histologically were typical hepatomas. Cells from these tumors were placed back into tissue culture and were transferr...