early screening of autism increases the chance of receiving timely intervention. using the parent report questionnaires is effective in screening autism. the q-chat is a new instrument that has shown several advantages than other screening tools. because there is no adequate tool for the early screening of autistic traits in iranian children, we aimed to investigate the adequacy of the persian ...

Chat (Cas/HEF1-associated signal transducer) is a novel signaling molecule with an N-terminal SH2 domain and C-terminal Cas/HEF1 association domain that is implicated in the regulation of cell adhesion. The Cas/HEF1 association domain also shows sequence similarity with guanine nucleotide exchange factors for Ras family small GTPases. In this study, we found significant activation of Rap1 in Ch...

Background: Myenteric interneurones are involved in the reflexes that control the motility of the human colon. Aims: The distribution of choline acetyltransferase (ChAT) and nitric oxide synthase (NOS) immunoreactivity in myenteric interneurones was investigated in this study. Methods: DiI (1,1′didodecyl 3,3,3′,3′-indocarbocyanine perchlorate) was applied to the myenteric plexus of the human co...

The M-transcript of human choline acetyltransferase (ChAT) produces an 82-kDa protein (82-kDa ChAT) that concentrates in nuclei of cholinergic neurons. We assessed the effects of acute exposure to oligomeric amyloid-β1-42 (Aβ1-42) on 82-kDa ChAT disposition in SH-SY5Y neural cells, finding that acute exposure to Aβ1-42 results in increased association of 82-kDa ChAT with chromatin and formation...

OBJECTIVE The purpose of the study was to examine use of the Modified Checklist for Autism in Toddlers (M-CHAT) as an autism-specific screening instrument in a large, geographically diverse pediatrics-based sample. METHODS The M-CHAT and the M-CHAT Follow-Up (M-CHAT/F) were used to screen 18,989 toddlers at pediatric well-child visits in 2 US geographic regions. Pediatricians directly referre...

Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduces ChAT enzyme activity and cellular protein levels, and is located within a highly-conserved N-terminal proline-rich motif at residues 14PKLPVPP20....

Chat language refers to the special human language widely used in the community of digital network chat. As chat language holds anomalous characteristics in forming words, phrases, and non-alphabetical characters, conventional natural language processing tools are ineffective to handle chat language text. Previous research shows that knowledge based methods perform less effectively in processin...

BACKGROUND Myenteric interneurones are involved in the reflexes that control the motility of the human colon. AIMS The distribution of choline acetyltransferase (ChAT) and nitric oxide synthase (NOS) immunoreactivity in myenteric interneurones was investigated in this study. METHODS DiI (1,1'- didodecyl 3,3,3',3'-indocarbocyanine perchlorate) was applied to the myenteric plexus of the human...