this study seeks to examine how a company can select the best intermediary for its marketing channels with minimum of criteria and time. a theoretical framework is proposed based on the most important tasks of intermediary and the criteria to measure them. there are four basic tasks and thirty criteria in three independent levels. subsequently, an exploratory case study in iranian food industry...

introduction: intracellular ph (phi) regulates essentially all aspects of cellular activities. however, it is unknown how endoplasmic reticulum (er) potassium channels sense phi. in this study, we investigate the direct effects of phi on er potassium channels. methods: we used channel incorporation into the bilayer lipid membrane method. l-α-phosphatidylcholine, a membrane lipid, was extracted ...

knowledge of habitat requirements of aquatic animals plays an important role in fisheries and protection programs of aquatic ecosystems. hence, this study was conducted to investigate the suitability indexes of habitat use and habitat suitability index (hsi) of barbus cyri in its distribution range in tootkabon river. a number of environmental variables, including elevation, water depth, river ...

We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or DNA, each polymer traverses the membrane as an extended chain that partially blocks the channel. The passage of each molecule is detected as a transient decrease of ionic curr...

We designed and built a microfluidic device for the generation of liquid jets produced by thermocavitation. A continuous wave (CW) laser was focused inside a micro-chamber filled with a light-absorbing solution to create a rapidly expanding vapor bubble. The chamber is connected to a micro-channel which focuses and ejects the liquid jet through the exit. The bubble growth and the jet velocity w...

Activation of ATP-sensitive potassium (KATP) channels in arterial smooth muscle (ASM) contributes to vasodilation evoked by a variety of endogenous and exogenous compounds. Although controversial, activation of KATP channels by neuropeptides such as calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) in the trigeminovascular system, including the mi...

Abstract There are few studies on the shape and structure of channel-type induction heating tundish multi-physics field. Computational fluid dynamics has been used to study influence macroscopic transport behavior with channel heating. The results show that increasing depth molten pool is conducive dynamic multiphase, deeper pool, larger active area, longer residence time, more inclusions remov...

Nerve injury frequently triggers hyperexcitability and the ectopic initiation of impulses in primary afferent axons. An important consequence is neuropathic paresthesias and pain. Electrogenesis in normal afferents depends on appropriate Na+ channel concentrations. Therefore, we have asked whether injury might trigger changes in axolemmal Na+ channel distribution that could account for neuropat...