CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...

Objective(s): Calcitonin gene related peptide (CGRP) receptors are widely distributed in the central nervous system. The aim of this study was to investigate the effects of intracerebroventricular (ICV) injection of CGRP on pain behavioral responses and on levels of monoamines in the periaqueductal gray area (PAG) during the formalin test in rats.Materials and Methods: Twenty-four male rats wer...

CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...

I. History and Discovery 904 A. Calcitonin gene-related peptide: a novel neuropeptide 904 B. Adrenomedullin: a tissue-derived peptide 905 C. Amylin: a pancreatic peptide 905 II. Structure 905 III. Distribution and Regulation of Genes and Peptides 906 A. CGRP: a wide distribution 906 B. AM: upregulation in disease 907 C. Amylin: relevance to diabetes 908 IV. Receptors 908 A. Cloning of CGRP rece...

Since nerve termini on Langerhans cells (LC) contain calcitonin gene-related peptide (CGRP), and since ultraviolet B radiation (UVR) causes CGRP to be released from cutaneous nerve endings, we examined whether CGRP participates in the immune aberrations caused in skin by UVR. First, intradermally injected CGRP, in a dose-dependent manner, reduced LC density and impaired CH induction when hapten...

The central nucleus of amygdala (CeA) plays an important role in pain regulation. Calcitonin gene-related peptide (CGRP)-like immunoreactive fibers and CGRP receptors are distributed densely in CeA. The present study was performed to elucidate the role of CGRP in nociceptive regulation in the CeA of rats. Intra-CeA injection of CGRP induced dose-dependent increases in the hind-paw withdrawal la...

Peptides related to the N-terminal region of calcitonin gene-related peptide (CGRP) were tested for their ability to modulate neuronal nicotinic acetylcholine receptors (nAChRs) of rat cultured chromaffin cells under whole cell patch-clamp conditions. Although CGRP(1-7) and CGRP(2-7) depressed responses mediated by nAChRs, CGRP(1-6), CGRP(1-5), or CGRP(1-4) rapidly and reversibly potentiated su...

Calcitonin gene-related protein (CGRP) inhibits food intake and stimulates the hypothalamo-pituitary-adrenal (HPA) axis after intracerebroventricular injection in rats. However, the hypothalamic site and mechanism of action are unknown. We investigated the effects of intraparaventricular nucleus administration (iPVN) of CGRP on food intake and the HPA axis in rats and the effect of CGRP on the ...

The neuropeptides substance P, calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) have been considered as important mediators in migraine and other primary headaches. CGRP and VIP have been found at increased concentrations in jugular venous plasma during attacks of migraine or cluster headache, and CGRP receptor antagonists have recently ...