AIM--To detect the presence or absence of Epstein-Barr virus (EBV) in cervical lesions ranging from normality to invasive malignancy. METHODS--Eighteen randomly selected cases of invasive squamous cell carcinomas of the uterine cervix were examined as well as 25 cases each of normal cervices and those showing cervical intra-epithelial neoplasia (CIN) I, II, and III. DNA-DNA in situ hybridisatio...

The surface layer of the cervix is made up of squamous and columnar epithelial cells. The area where these two cells meet around the opening of the cervix that leads on to the endocervical canal is called the transformation zone or squamo-columnar junction. It is in this area of the cervix where cervical cells are most likely to become cancerous. Approximately 75% of cervical cancers are squamo...

Aim: To investigate epithelial and stromal metabolite changes in cervical intraepithelial neoplasia [CIN] and cervical cancer in vivo and correlate findings with MR spectroscopy of tissue samples. Methods: Forty-seven women (19 with CIN, 28 with cervical cancer) underwent endovaginal MR at 1.5T with T2-W and localized 2-D MR spectroscopic imaging (PRESS, TR=1500ms, TE=135ms). tCho, 2ppm and -CH...

INTRODUCTION To describe the prevalence of human papillomavirus infection (HPV) in cases of cervical intra-epithelial neoplasia (CIN), micro-invasive carcinoma and invasive carcinoma in Toluca, State of Mexico. MATERIALS AND METHODS Cross-sectional study analysing slides with the diagnosis of CIN I to invasive carcinoma for one year and reporting the presence of HPV; also identifying these ce...

Human papillomavirus (HPV) high risk genotype infection and HPV viral load influences the development of invasive cervical cancer and cervical intra-epithelial neoplasia (CIN). HPV DNA testing for screening of cervical cancers may play a potential role in its early detection and management. The present study detected HPV DNA and estimated HPV viral load in different types of cervical lesions am...

Accurate cervical intra-epithelial neoplasia (CIN) lesion grading is needed for effective patient management. We applied computer-assisted scanning and analytic approaches to immuno-stained CIN lesion sections to more accurately delineate disease states and decipher cell proliferation impacts from HPV and smoking within individual epithelial layers. A patient cohort undergoing cervical screenin...

AIM OF THE STUDY Aim of the study was to estimate the incidence of unexpected premalignant gynecological lesions in women undergoing vaginal hysterectomy for utero-vaginal prolapse. MATERIAL AND METHODS Eighty women with asymptomatic utero-vaginal prolapse were included in this prospective study for vaginal hysterectomy after preoperative preparation and after written informed consent. Women ...

Objective: Cervical cancer is caused by human papilloma virus (HPV) infection, and cervical intraepithelial neoplasia (CIN) a precancerous lesion. Common treatments for CIN are conization laser vaporization. HPV testing useful predicting residual or recurrent disease after surgical treatment. We performed high-risk (HR-HPV) genotyping postoperatively to examine the positivity rate determine whe...

PURPOSE We aimed to investigate the expression of EGFR and the autophagy-related markers Beclin1 and LC3 in cervical cancer. METHODS Beclin1, LC3, and EGFR expression were analyzed in 80 samples of cervical squamous cell carcinoma (SCC), 40 samples of high-grade cervical intraepithelial neoplasia (CIN), and 40 samples of normal cervical tissues by immunohistochemistry. The protein expression ...

prostatic intra-epithelial neoplasia (pin) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. in this study, we applied the pin grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of pro...