Numerous case-control studies on the association between polymorphisms of key genes involved in methionine remethylation [methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS)] and the susceptibility of cervical intraepithelial neoplasia (CIN) and cervical cancer have provided inconclusive results. The aim of the present meta-analysis was to determine the effects of two MTHFR...

Cancer prevalence particularly for cervical cancer (CC) has been steadily increasing tending to rise among young women. Vigorous antitumor treatment approaches employed in CC management have detrimental effects on various aspects of a woman's life. In addition causing morphofunctional alterations diverse host organs and systems, such protocols result psychological emotional disturbances, sexual...

Introduction: In the current study we evaluated the incremental value of lateral pelvic lymphoscintigraphy imaging of endometrial or cervical cancer patients who underwent sentinel node mapping. Methods: Operable endometrial and cervical cancer patients without clinical or paraclinical evidence of lymph node involvement were included in the study. The day before surgery the patients were sent ...

Objective: Cervical cytology (CC) is a routine screening method used to reduce cervical cancer. Although anal cancer and have similar etiological factors the opinion about program unclear. We aimed determine features of women with abnormal (AC) who had screened via CC for neoplasia.
 
 Methods: Two hundred five females' results were investigated. The patients normal excluded, finally ...

Objective(s):Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in cervical cancer (CC). However, the molecular mechanisms are unclear. This study aimed to investigate the molecular mechanism of eIF4E gene overexpression in CC. Materials andMethods:The human papillomavirus (HPV) type 18 E7 and eIF4E mRNAs were measured following knock down or overexpression of E7 gene by RT-P...

OBJECTIVE This study was conducted to identify whether polymorphic variants of set domain-containing protein 8 (SET8) and tumor protein p53 (TP53) codon 72, either independently or jointly, might be associated with increased risk for cervical cancer. METHODS We genotyped SET8 and TP53 codon 72 polymorphisms of peripheral blood DNA from 114 cervical cancer patients and 200 controls using the p...

In recent years, long noncoding RNAs (lncRNAs) have been demonstrated to play key roles in tumorgenesis. However, the contributions of lncRNAs to cervical cancer (CC) remain largely unknown. In this study, differentially expressed lncRNAs and mRNAs in cervical cancer and paired peritumoral tissues were detected by transcriptome microarray analysis. We found 708 probe sets of lncRNAs increased a...

OBJECTIVE To evaluate the association between interleukin-12 (IL-12) gene polymorphism and cervical cancer susceptibility. METHODS We comprehensively retrieved the relevant English and Chinese database to collect case-control studies on the association between the IL-12 gene polymorphism and cervical cancer susceptibility. Data were extracted independently by two researchers respectively, the...

BACKGROUND Cervical Cancer (CC) is the number one cancer among women in sub-Saharan Africa. Although CC is preventable, most women in developing countries do not have access to screening. METHODS This cross-sectional study was conducted to determine the prevalence and risk factors for cervical lesions using visual inspection with acetic acid (VIA) among 112 HIV positive and 161 negative women...

Cervical cancer (CC) has been identified as a leading cause of cancer-related death women in Nigeria. Unfortunately, treatment for CC induces renal function injury due to nephrotoxicity commonly used cytotoxic medications and radiotherapy. The aim this study was determine whether radiotherapy consistently impairs the cervical patients after claimed by literature. an ex post facto research, retr...