AIM To study the relationship between age-related maculopathy (ARM) and exposure to sunlight using an objective method. METHODS In a case-control study of Japanese men aged > or = 50 years (67 controls without ophthalmic disease and 148 with ARM), those with ARM were separated into groups of early (n = 75) and late (n = 73) ARM. Facial wrinkle length and area of hyperpigmentation, which are c...

This study evaluated the effects of a manganese peptide complex in the treatment of various signs of cutaneous facial photodamage. Individuals used a facial serum formulation containing the manganese peptide complex Manganese Tripeptide-1 twice a day for up to 12 weeks. At the end of the treatment period, the individuals and a blinded investigator noted improvement in the appearance of several ...

OBJECTIVE To evaluate the long-term effectiveness of, and the complications associated with, carbon dioxide laser treatment of rhytidosis and solar aging. METHODS This retrospective report describes our experience with 47 patients who underwent entire facial carbon dioxide laser resurfacing. RESULTS The mean improvement in facial rhytid score at long-term follow-up was 45%. This improvement...

Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma...

1 MD; MSc in Sciences. Otorhinolaryngologist and Head and Neck Surgeon Hospital São José e Centro Hospitalar Unimed Joinville SC. 2 MD. Chest Surgeon Hospital São José e Centro Hospitalar Unimed Joinville SC. 3 MD; Head and Neck Surgeon and Maxillo-Facial-Skull Surgeon -SC. Hospital das Clínicas da UFMG. Send correspondence to: Catia Rodrigues Domingos. Rua João Ribeiro, no 303, apto 302. Belo ...

Demodex mites may induce inflammatory cutaneous reactions such as papulopustular rosacea and demodex folliculitis; both may lead to post inflammatory pigmentation. A 59-year-old man presented with an asymptomatic, hyperpigmented plaque on his face. Histological and clinical findings displayed Riehl-like facial pigmentation. Multiple demodex mites at the follicular infundibulum in the biopsy mat...

INTRODUCTION Hydroquinone is the best studied andmost widely used topical depigmenting agent, and represents the gold standard for treatment of disorders of pigmentation. Although ochronosis is a known sequela of long-term hydroquinone use, pigmentation of the nails is rarely a reported side effect. We present a case of identical twins who developed hyperpigmentation of identical nails after th...

An uncommon coexistence of circumscribed hyperpigmentation and hypopigmentation, in close proximity to each other, is described in a 17 years old patient with various other cogenital defects, such as dysmorphic facial appearance, severe kyphoscoliosis, delayed motor development, epileptic seizures, and mental retardation. We suggest the combination of hyper- and hypopigmented cutaneous lesions ...