A trimethylated amino acid roughly similar in structure to choline, carnitine is a cofactor required for transformation of free long-chain fatty acids into acylcarnitines, and for their subsequent transport into the mitochondrial matrix, where they undergo beta-oxidation for cellular energy production. Mitochondrial fatty acid oxidation is the primary fuel source in heart and skeletal muscle, p...

background and aim: in skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation. despite an abundance of literature describing the basic mechanisms of action of l-carnitine metabolism, there remains some uncertainty regarding the effects of oral l-carnitine supplementation on metabolism and exer...

Background: The benefit effect of L-carnitine is proposed for treatment of obesity as long time periods. So, in the present study, effect of L-carnitine on serum FSH, LH and testosterone levels in adult male rats is evaluated. Materials and Methods: Rats were treated different doses of L-carnitine tartarate daily for 16 days, peritoneally. The control group was treated saline as vehicle. After ...

l-carnitine as a water soluble derivative of lysine has a crucial biological role in lipid metabolism. present experiment was conducted to study the effect of l-carnitine supplementation into broiler and/or breeder diets on broilers' performance, blood related factors, carcass characteristics and immune system. l-carnitine was added to the broiler breeder's diets at levels of 0, and 6...

Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO the final product of complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates panel metabolites involved TMAO-choline/carnitine for their associations outcome acute HF patients. In total, 806 plasma sample...

Growth performance, food efficiency and body composition of pikeperch (Sander lucioperca) were investigated with 1 or 2 g/kg L-carnitine added to the diet. Control diet did not contain L-carnitine. Two hundred pikeperch fingerlings (1.63 g, mean weight) were stocked in each 1 m3 concrete tank and fed equally 6 meals per day for 6 weeks. Higher increment in body weight (5.92 ± 0.37 g), the ...

background: to determine any correlation between infertility and semen quality with concentrations of l-carnitine in human seminal plasma. methods: this case-control study performed in fatemieh hospital in hamadan, iran. seminal plasma of 72 infertile men and 80 men with proved fertility as a control group was investigated and l-carnitine level was determined using uv enzymatic test at 340 nm. ...

introduction: in the present study, potential differences between the effects of l-carnitine (lc) and acetyl-lcarnitine (alc) on ischemia/reperfusion (i/r)-induced myocardial infarction size were investigated. methods: male wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. hearts of the animals were removed and quickly mounted on a langendorff app...

PURPOSE To investigate the pharmacokinetics of L-carnitine (LC) and its analogues, acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) in healthy volunteers after single L-carnitine administration. METHODS Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Plasma and urine concentrations of L-carnitine, ALC and PLC were detected by HPLC. RESULTS...