A 36-year old woman presented with a dark spot in her right eye for one week. She had a history of systemic lupus erythematosus (SLE) diagnosed on the basis of ANA positivity with a 1:320 titer, joint swelling, butterfly rash, idiopathic thrombocytopenic purpura and anti-phospholipid syndrome with positive anti-cardiolipin antibodies. She had been diagnosed with lupus choroidopathy two months p...

UNLABELLED Here, we report about a boy (age: 18 years) who developed an acquired factor VIII inhibitor at the age of 9 years. He presented with bleeding in his right ankle, multiple haematomas and a high-titer factor VIII type II inhibitor (400 BU). THERAPY He received treatment with MMF (CellCept®), dexamethasone-immunoglobulin pulses, and rituximab together with high dose FVIII (Hannover pr...

Here, we report about a boy (age: 18 years) who developed an acquired factor VIII inhibitor at the age of 9 years. He presented with bleeding in his right ankle, multiple haematomas and a high-titer factor VIII type II inhibitor (400 BU). Therapy: He received treatment with MMF (CellCept®), dexamethasoneimmunoglobulin pulses, and rituximab together with high dose FVIII (Hannover protocol). His ...

APRIL 2010 CATARACT & REFRACTIVE SURGERY TODAY 33 F or more than 6 decades, topical corticosteroids have been the cornerstone of therapy for the treatment of various forms of ocular inflammation, both surgical and autoimmune in nature.1 By inhibiting the release of phospholipase A2 early in the inflammatory cascade, steroids provide a broad range of anti-inflammatory activity, because they atte...

We report our clinical experience with rituximab in the treatment of 2 patients with idiopathic cutaneous angiitis who relapsed after treatment with high-dose corticosteroids and cyclophosphamide. A 39-year-old woman and a 51-year-old man presented with ulcerating maculopapular rash in both lower limbs which relapsed 6 months after treatment with a combination of high-dose corticosteroids and c...

Mycophenolate mofetil (MMF) is an immunosuppressive agent indicated for the prophylaxis of acute rejection in patients receiving allogeneic renal, cardiac, or hepatic transplants. It is a Biopharmaceutics Classification System Class II substance that has a strongly pH-dependent solubility profile. Consequently, differences in solid-state properties, formulation, and manufacturing processes of M...

summary: adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. it is characterized by high grade fever, skin rash, arthritis, leukocytosis, increased esr, crp and liver enzyme levels and high levels of ferritin. the treatment of aosd includes nsaids, steroids, and disease-modifying antirheumatic drugs (dmards). recently biologic agents have been used f...