نتایج جستجو برای: cell hypoxia
تعداد نتایج: 1724699 فیلتر نتایج به سال:
Background: Brain hypoxia-ischemia is a human neonatal injury that is considered a candidate for stem cell therapy. Methods: The possible therapeutic potential of human umbilical cord blood (HUCB) stem cells was evaluated in 14-day-old rats subjected to the right common carotid occlusion, a model of neonatal brain hypoxia-ischemia. Seven days after hypoxia-ischemia, rats received either saline ...
Abstract Backgraound: Hypoxia is an important determinant for biological behavior of malignant solid tumors. In vitro and in vivo studies have shown that tumor hypoxia is associated with an increased likelihood of local recurrence and distant metastasis, as well as resistance to radiation therapy and certain types of chemotherapy. Studies have shown that some copper-bis thiosemicarbazones es...
introduction: oxygen tension is one of the most important stimuli in stem cell biology. in this study, we investigate the considerable influence of hypoxia on cx43 gene expression as one of the most important gap junction on the surface of mesenchymal stem cells. methods: mesenchymal stem cells were isolated from c57bl/6 mouse bone marrow and cultured in dmem medium under low oxygen tension (1%...
The aim of the present study was to determine mRNA expression profiles TRAIL-mediated cell death related genes hypoxia-tolerant rodent Nannospalax nehringi under hypoxia. nucleotide and amino acid sequences these were identified. Captured randomly divided into normoxia hypoxia groups. group exposed a 7% O2 + 93% N2 gas mixture for 52 h, while animals in housed normoxic conditions. Total RNAs is...
Background and purpose: Imbalance between low oxygen supply and oxygen demands determines organ hypoxia causing oxidative stress and finally lead to cell death. Compounds with antioxidant activity are able to exhibit antihypoxic property. Allium sativum has distinctive antioxidant activities, but to the best of our knowledge, there is no reports on the protective effect of flower of this plant ...
Background: Anemia and consequently low oxygen can cause changes in the function and structure of the testis and spermatogenesis, Iron released from red blood cells, followed by the increased oxidative stress, which may cause tissue iron. This study was designed to minimize the deleterious effects of hypoxia on the genitals. Materials and Methods: Eighteen mature male mice were randomly divided...
macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...
It is well known that the metabolic factors play an important role in the regulation of angiogenesis. Increased metabolic activity leads to decreased oxygen levels and causes tissue hypoxia. Hypoxia starts different signals to stimulate angiogenesis and promotes oxygen delivery to tissues. It has been suggested that released adenosine from hypoxic tissues plays a vital role in angiogenesis. ...
The relationship between sickle cell disease (SCD), hearing and cognitive impairment is intertwined due to the vaso-occlusive, vascular insults tissue hypoxia associated with disease.
Angiogenesis, as the process of new vessel formation from pre-existing vessels is dependent on a delicate equilibrium between endogenous angiogenic and antiangiogenic factors. However, under pathological conditions, this tight regulation becomes lost which can result in the formation of the different diseases such as cancer. Angiogenesis is a complex process that includes many gene products tha...
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