Peripheral sensory organs provide the first transformation of sensory information, and understanding how their physical embodiment shapes transduction is central to understanding perception. We report the characterization of surface transduction during active sensing in the rodent vibrissa sensory system, a widely used model. Employing high-speed videography, we tracked vibrissae while rats sam...

Much of current understanding of cell motility arose from studying steady treadmilling of actin arrays. Recently, there have been a growing number of observations of a more complex, non-steady, actin behavior, including self-organized waves. It is becoming clear that these waves result from activation and inhibition feedbacks in actin dynamics acting on different scales, but the exact molecular...

Abstract Preclinical human‐relevant modeling of organ‐specific vasculature offers a unique opportunity to recreate pathophysiological intercellular, tissue‐tissue, and cell‐matrix interactions for broad range applications. Here, this work presents reliable, simply reproducible process constructing user‐controlled long rounded extracellular matrix (ECM) embedded vascular microlumens on‐chip endo...

purpose: to evaluate corneal hysteresis and corneal resistance factor in penetrating keratoplasty grafts in a group of keratoconic eyes using the ocular response analyzer (ora) and to evaluate the relationship between donor size, donor-recipient disparity and central graft thickness (cgt), and ora parameters. methods: this cross-sectional study was conducted on 34 eyes of 34 keratoconus patient...

background and objectives: it has been shown that a bout of jumping exercise with weighted vests increases the subsequent countermovement jump height. however, it is not clear whether the improvement in jump height is due to the enhancement of joint power or due to other mechanisms such as neural adaptations. methods: to investigate this dichotomy, we tested the acute neuromechanical changes fo...

The application of mechanics to biology--biomechanics--bears great challenges due to the intricacy of living things. Their dynamism, along with the complexity of their mechanical response (which in itself involves complex chemical, electrical, and thermal phenomena) makes it very difficult to correlate empirical data with theoretical models. This difficulty elevates the importance of useful bio...

Cellular biomechanics play a pivotal role in the pathophysiology of several diseases. Unfortunately, current methods to measure biomechanical properties are invasive and mostly limited to the surface of a cell. As a result, the mechanical behaviour of subcellular structures and organelles remains poorly characterised. Here, we show three-dimensional biomechanical images of single cells obtained...