نتایج جستجو برای: ceftiofur hydrochloride
تعداد نتایج: 44726 فیلتر نتایج به سال:
• Concentrations of ceftiofur and related metabolites in interstitial fluid* serve as a better indicator of target-site drug concentrations than do plasma concentrations. • Plasma and infected chamber interstitial fluid concentrations of ceftiofur and related metabolites were above the efficacy threshold** 9 days after subcutaneous administration of EXCEDE (ceftiofur crystalline free acid) Ster...
Ceftiofur is third generation cephalosporin, broad spectrum antibiotic. It inhibits the cell wall synthesis of bacteria. Ceftiofur is widely used in animals for the treatment of various diseases. Ceftiofur is used against Gram positive and Gram negative bacteria. It has been approved world widely for the treatment of respiratory diseases in sheep, goats, cattle and horses. Ceftiofur sodium phar...
The U.S. Food and Drug Administration recently issued new rules for using ceftiofur in food animals in part because of an increasing prevalence of enteric bacteria that are resistant to 3(rd)-generation cephalosporins. Parenteral ceftiofur treatment, however, has limited effects on enteric bacteria so we tested the hypothesis that excreted ceftiofur metabolites exert significant selection press...
The Canadian Integrated Program for Antimicrobial Resistance Surveillance describes a strong correlation (r = 0.9, p<0.0001) between ceftiofur-resistant Salmonella enterica serovar Heidelberg isolated from retail chicken and incidence of ceftiofur-resistant Salmonella serovar Heidelberg infections in humans across Canada. In Quebec, changes of ceftiofur resistance in chicken Salmonella Heidelbe...
Antimicrobial use in food animals may contribute to antimicrobial resistance in bacteria of animals and humans. Commensal bacteria of animal intestine may serve as a reservoir of resistance-genes. To understand the dynamics of plasmid-mediated resistance to cephalosporin ceftiofur in enteric commensals of cattle, we developed a deterministic mathematical model of the dynamics of ceftiofur-sensi...
Salmonella is the leading cause of known food-borne bacterial infections in the United States, with an incidence rate of approximately 15 cases per 100,000 people. The rise of antimicrobial-resistant Salmonella subtypes, including the appearance of subtypes resistant to ceftriaxone, represents a particular concern. Ceftriaxone is used to treat invasive cases of Salmonella in children and is clo...
Ceftiofur is a third-generation cephalosporin antibiotic that has been widely used to treat bacterial infections in concentrated animal feeding operations (CAFOs). Land application of CAFO waste may lead to the loading of ceftiofur residues and its metabolites to the environment. To understand the potential contamination of the antibiotic in the environment, the degradation kinetics and mechani...
The stability of the broad-spectrum antibiotic ceftiofur was studied in order to investigate the kinetics of photodegradation of this drug, using a stability-indicating liquid chromatography (LC) method. The degradation was carried out in aqueous solutions, prepared from reference substance and two pharmaceutical products (Excenel and Topcef) containing sodium ceftiofur powder for injection, in...
OBJECTIVE To compare the minimum inhibitory concentration (MIC) of cephapirin and ceftiofur with MICs of their active metabolites (desacetylcephapirin and desfuroylceftiofur) for selected mastitis pathogens. SAMPLE 488 mastitis pathogen isolates from clinically and subclinically affected cows in commercial dairy herds in Wisconsin. PROCEDURES Agar dilution was used to determine MICs for Sta...
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