نتایج جستجو برای: cebpα
تعداد نتایج: 61 فیلتر نتایج به سال:
Pulmonary surfactant has been used as a carrier to deliver a therapeutic virus to dysfunctional lung cells that reside within an intricate lung structure. To investigate whether pulmonary surfactant enhances the efficacy of intratracheal instillation of a therapeutic virus to target KRAS mutation-bearing lung cancer in vivo, we developed a recombinant adenovirus that induces cell death only in ...
We retrospectively investigated the prognostic factors of acute myeloid leukemia (AML) in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital. Log-rank test showed that 6 parameters including older age, higher white blood cell (WBC) counts, lactate dehydrogenase (LDH) and bone marrow (BM) blasts at diagnosis, unfavorable risk cyto...
Transcription factors (TFs) represent key factors to establish a cellular phenotype. It is known that several TFs could play a role in disease, yet less is known so far how their targets overlap. We focused here on identifying the most highly induced TFs and their putative targets during human adipogenesis. Applying chromatin immunoprecipitation coupled with deep sequencing (ChIP-Seq) in the hu...
Recurrent genomic abnormalities identified in acute myeloid leukemia (AML) improve prognostic stratification of patients with normal karyotype AML AML (NK-AML).1, 2 Retrospective studies show that mutations in FLT3, NPM1, and CEBPα are powerful tools to predict outcomes in younger and older patients with NK-AML.3-5 Limited data exists on the role of allogeneic hematopoietic cell transplant (HCT...
Although ginsenosides Rb1 and Rg3 have been identified as the significant found in red ginseng that confer anti-diabetic actions, it is unclear whether insulin-sensitizing effects are mediated by individual compounds or their combination. To determine effect of on adipocyte differentiation, 3T3-L1 preadipocytes were induced to differentiate standard hormonal inducers absence presence Rg3. Addit...
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcript...
Lymph node development during embryogenesis involves lymphotoxin-β receptor engagement and subsequent differentiation of a poorly defined population of mesenchymal cells into lymphoid tissue organizer cells. Here, we showed that embryonic mesenchymal cells with characteristics of adipocyte precursors present in the microenvironment of lymph nodes gave rise to lymph node organizer cells. Signali...
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