canine distemper virus (cdv) creates a very contagious viral multi-systemic canine distemper (cd) disease that affects most species of carnivora order. the virus is genetically heterogeneous, particularly in section of the hemagglutinin (h) gene. sequence analysis of the h gene can be useful to investigate distinction of various lineages related to geographical distribution and cdv molecular ep...

PURPOSE To determine the antiviral resistance of three cidofovir (CDV)-resistant variants of adenovirus type 5 (Ad5) and their ability to replicate in the New Zealand White rabbit ocular model. METHODS Rabbits were inoculated topically in both eyes with the CDV-resistant variants R1, R2, and R3, and the Ad5 parental strain. On day 1, rabbits from each virus inoculation were divided into two t...

Canine distemper is a highly contagious and immunosuppressive viral disease caused by canine distemper virus (CDV), an enveloped RNA virus of the family Paramyxoviridae. The susceptible host spectrum of CDV is broad and includes all families of the order Carnivora. To accomplish the infection, CDV requires an expression of signaling lymphocyte activation molecule (SLAM) functioning as a cellula...

Canine distemper virus (CDV) has been reported worldwide in wild carnivores and has been cited as the cause of population declines in some species. Crab-eating foxes (Cerdocyon thous) from El Palmar National Park, Argentina, were observed either dead or exhibiting clinical neurologic signs. Samples were taken from two individuals that were laterfound tobe positive for CDV by direct immunofluore...

Canine distemper virus (CDV) has a wide host spectrum, and during the past years, distemper has been observed in species that were previously not considered to be susceptible. In this study, we investigated the prevalence of CDV-specific antibodies in red foxes (Vulpes vulpes) sampled between May and November 1997. About 9 to 13% of the Luxembourg red fox population is positive for antibodies a...

BACKGROUND Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir (CDV) with increased in vitro potency relative to CDV against all 5 families of double-stranded DNA viruses that cause human disease. After intravenous (IV) administration of CDV, the organic anion transporter 1 (OAT1) transports CDV from the blood into the renal proximal tubule epithelial cells with resulting...

Supraphysiological reactive oxygen species (ROS) has been linked to a variety of diseases, including cancer, inflammation, and neurodegeneration. One the diseases pathophysiologically associated with ROS accumulation is canine distemper (CD). The purpose this study was compare lipid peroxidation antioxidant biomarkers in dogs infected virus (CDV) healthy dogs. animals consisted total 20 dogs, 1...

Cidofovir (CDV) is an effective therapy for certain human cytomegalovirus (HCMV) infections in immunocompromised patients that are resistant to other antiviral drugs, but the compound is not active orally. To improve oral bioavailability, a series of lipid analogs of CDV and cyclic CDV (cCDV), including hexadecyloxypropyl-CDV and -cCDV and octadecyloxyethyl-CDV and -cCDV, were synthesized and f...

Canine distemper virus (CDV) is a morbillivirus that is the etiological agent of one of the most important viral diseases affecting canids and an expanding range of other carnivores. Using real-time RT-PCR, CDV RNA was detected in organs of an Iberian lynx (Lynx pardinus) found dead in the Doñana National Park, Southwestern Andalusia, Spain. This finding may be of great importance for the conse...

This report describes the naturally occurring atypical neuropathological manifestation of systemic canine distemper virus (CDV) infection in two 16-day-old Pit Bull pups. CDV-induced changes affected the gray and white matter of the forebrain while sparing the hindbrain. Histologically, there was necrosis with destruction of the nervous parenchyma due to an influx of inflammatory and reactive c...