نتایج جستجو برای: cd80

تعداد نتایج: 2396  

Journal: :Annals of the rheumatic diseases 2001
R Matsumura K Umemiya T Goto T Nakazawa M Kagami H Tomioka E Tanabe T Sugiyama M Sueishi

OBJECTIVES To investigate the expression and regulation of CD80, CD86, and CD28 costimulatory molecules in sialoadenitis and interstitial nephritis in patients with Sjögren's syndrome (SS). METHODS Expression of CD80, CD86, and CD28 molecules was studied by immunohistochemical staining of lip biopsy specimens obtained from patients who had sialoadenitis associated with SS, and renal biopsy sp...

Journal: :Journal of virology 2012
Jens Eberlein Bennett Davenport Tom T Nguyen Francisco Victorino Tim Sparwasser Dirk Homann

The lymphocytic choriomeningitis virus (LCMV) system constitutes one of the most widely used models for the study of infectious disease and the regulation of virus-specific T cell immunity. However, with respect to the activity of costimulatory and associated regulatory pathways, LCMV-specific T cell responses have long been regarded as relatively independent and thus distinct from the regulati...

Journal: :International immunology 2003
Victorine Douin-Echinard Jean-Marie Péron Valérie Lauwers-Cancès Gilles Favre Bettina Couderc

CD70 and CD80 are co-stimulatory molecules which belong to the tumor necrosis factor family and the B7 family respectively. When they are co-expressed by gene-modified TS/A tumor cells, they provide an efficient protective and long-lasting T-dependent antitumor response. We first showed that when CD70 and CD80 were delivered in the tumor environment by gene-modified fibroblasts, but were not ex...

2016
Elias A. Said Iman Al-Reesi Marwa Al-Riyami Khalid Al-Naamani Shadia Al-Sinawi Mohammed S. Al-Balushi Crystal Y. Koh Juma Z. Al-Busaidi Mohamed A. Idris Ali A. Al-Jabri

BACKGROUND The failure to establish potent anti-HBV T cell responses suggests the absence of an effective innate immune activation. Kupffer cells and liver-infiltrating monocytes/macrophages have an essential role in establishing anti-HBV responses. These cells express the costimulatory molecules CD80 and CD86. CD80 expression on antigen-presenting cells (APCs) induces Th1 cell differentiation,...

Journal: :Archivum immunologiae et therapiae experimentalis 2003
Ryszard Rutkowski Tadeusz Moniuszko Anna Stasiak-Barmuta Bozena Kosztyła-Hojna Marek Alifier Krzysztof Rutkowski Anetta Tatarczuk-Krawiel

CD80 and CD86 seem to play an important role in the allergen-induced secretion of interleukin (IL)-5 and IL-13. Up to now, the expressions of CD80 (B7.1) and CD86 (B7.2) on monocytes and the kinetics of the expression of these molecules on lipopolysaccharide-stimulated monocytes in nonatopic asthma have not been defined. Using monoclonal antibodies, we have compared the expressions of CD80 (B7....

Journal: :Journal of immunology 2008
Su-Yi Tseng Janelle C Waite Mengling Liu Santosha Vardhana Michael L Dustin

Short-lived TCR microclusters and a longer-lived protein kinase Ctheta-focusing central supramolecular activation cluster (cSMAC) have been defined in model immunological synapses (IS). In different model systems, CD28-mediated costimulatory interactions have been detected in microclusters, the cSMAC, or segregated from the TCR forming multiple distinct foci. The relationship between TCR and co...

Journal: :The Journal of Experimental Medicine 1997
Nicola Harris Robert Peach Joe Naemura Peter S. Linsley Graham Le Gros Franca Ronchese

CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood. We created a mutant version of CTLA4-Ig that could selectively bind CD80 and block CD28-CD80 interaction but leave CD28-CD86 binding intact. CD8...

Journal: :Journal of immunology 2007
Femke van Wijk Stefan Nierkens Wilco de Jong Ellen J M Wehrens Louis Boon Peter van Kooten Léon M J Knippels Raymond Pieters

Dendritic cells are believed to play an essential role in regulating the balance between immunogenic and tolerogenic responses to mucosal Ags by controlling T cell differentiation and activation via costimulatory and coinhibitory signals. The CD28/CTLA-4-CD80/CD86 signaling pathway appears to be one of the most important regulators of T cell responses but its exact role in responses to orally a...

Journal: :The Journal of Experimental Medicine 1995
C A Fargeas A Truneh M Reddy M Hurle R Sweet R P Sékaly

The CD80 (B7-1) molecule is a 45-60-kD member of the immunoglobulin superfamily that is expressed on a variety of cell types of haematopoietic origin. CD80 can provide a critical costimulatory signal to T cells by interacting with the T cell surface molecule CD28. CD80 also binds to the CD28-related molecule CTLA4, which is expressed on activated T cells, Recently, additional ligands of CD28 an...

2017
Juan Liao Xiao-Chuan Wu Qia Cheng Can-Lin Li Zhu-Wen Yi Yan Cao Lan-Jun Shuai

PURPOSE The current study is aimed at investigating whether urinary CD80 is reliable to predict the recurrence of pediatric PNS. MATERIALS AND METHODS A total of 128 children, 105 males and 23 females, were enrolled in this study. Urinary samples were collected from SSNS and SRNS patients and 25 healthy children as controls. Urinary CD80 was measured by ELISA and adjusted for urinary creatini...

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