Early interferon-gamma (IFN-γ) release by innate cells is critical to direct type 1 immune response able to control intracellular pathogens like Trypanosoma cruzi. Although CD56(bright) natural killer (NK) cells are reported to be potent early IFN-γ producers, other CD56(+) cells like CD56(dim) NK cells and NK-like T cells have recently been shown to also release IFN-γ. We have here studied the...

The lack of natural killer (NK) cell-specific markers, as well as the overlap among several common surface antigens and functional properties, has obscured the delineation between NK cells and dendritic cells. Here, novel subsets of peripheral blood CD3/14/19(neg) NK cells and monocyte/dendritic cell (DC)-like cells were identified on the basis of CD7 and CD4 expression. Coexpression of CD7 and...

177 xxx They analyzed 651 patients with APL of whom 72 expressed CD56 (11%). CD56 + APL was significantly associated with high white blood cell counts, low albumin levels, the BCR3 isoform and coexpression of the CD2, CD34, CD7, HLA-DR, CD15 and CD117 antigens. For CD56 + APL, the 5-year relapse rate was 22% compared with a 10% relapse rate for CD56-APL (p-value = 0.006). CD56 + APL also showed...

NK cells are essential for health, yet little is known about human NK turnover in vivo. In both young and elderly women, all NK subsets proliferated and died more rapidly than T cells. CD56(bright) NK cells proliferated rapidly but died relatively slowly, suggesting that proliferating CD56(bright) cells differentiate into CD56(dim) NK cells in vivo. The relationship between CD56(dim) and CD56(b...

The aim of this study was to characterize NK (CD56(+)CD3(-)) and NKT-like cell (CD56(+)CD3(+)) responses early after chikungunya infection. Expression profiling and functional analysis of T/NK/NKT-like cells were performed on samples from 56 acute and 31 convalescent chikungunya patients and 56 control individuals. The percentages of NK cells were high in both patient groups, whereas NKT-like c...

PURPOSE To investigate the effects of combined low-dose cyclosporine and prednisone (Cs/Pd) treatment on circulating CD56+ T cells in patients with Behçet's uveitis. METHODS Ten patients with Behçet's uveitis and 10 healthy control subjects were prospectively recruited. The patients were treated with Cs/Pd for 2 months. Phenotypic and functional changes in circulating CD56+ T cells were assay...

background and aims. odontogenic cysts and tumors have a wide spectrum of clinical characteristics that lead to the different management strategies. since definite diagnosis is difficult in some cases, it has been suggested that cd56 may be a candidate marker for definitive diagnosis of some odontogenic tumors. the present study was designed to examine cd56 expression in lesions with histopatho...

background: there are inter-observer disagreements between papillary thyroid carcinoma (ptc) with other follicular lesions of thyroid in aspect of diagnosis. cd56 is present on follicular epithelial cells of the normal thyroid. we evaluated the diagnostic value of cd56 expression in ptc, follicular thyroid lesions, and follicular thyroid neoplasms. materials and methods: seventythree cases diag...

In mouse models of chronic inflammatory diseases, Natural Killer (NK) cells can play an immunoregulatory role by eliminating chronically activated leukocytes. Indirect evidence suggests that NK cells may also be immunoregulatory in humans. Two subsets of human NK cells can be phenotypically distinguished as CD16(+)CD56(dim) and CD16(dim/-)CD56(bright). An expansion in the CD56(bright) NK cell s...