Abstract The tumor microenvironment (TME), including the non-tumor cells and extracellular matrix (ECM) plays a crucial role in progression metastasis. Hyaluronic acid (HA), major glycosaminoglycan present brain ECM, has long been associated with invasiveness of tumors. HA signals primarily thorough CD44, an adhesion/homing receptor leading to induction cellular AKT, MEK HIF signaling, thereby ...

Background/Aim: We have tested whether the anticancer peptide, PNC-27, that kills cancer cells but not normal by binding to cell membrane HDM-2 forming pores, CD44+ colon stem cells. Materials and Methods: Flow cytometry determined CD44 expression on six-colon lines one line (CCD-18Co). MTT, LDH release, annexin V caspase 3 assays were used assess PNC-27-induced death. Bioluminescence imaging m...

CD44 is a transmembrane glycoprotein, the variant isoforms of which are coded for by alternative splicing, with the most prolific isoform being CD44 standard. CD44 is found in a wide variety of tissues including the central nervous system, lung, epidermis, liver, and pancreas, whereas variant isoforms of CD44 (CD44v) appear to have a much more restricted distribution. Variants of CD44 are expre...

Purpose of the study. Determine content cancer stem cells (CSCs) in tumor tissue (TT) and perifocal tissues (PT) muscle-non-invasive bladder cancer. Materials methods. We’ve examined fragments TT PT 7 (NMIBC) after surgical intervention – transurethral resection urinary (TUR). In samples that were used to obtain cell suspension using BD Medimachine apparatus (BD, USA) was treated with monoclona...

CD44 is a widely expressed integral membrane glycoprotein that serves as a specific adhesion receptor for the extracellular matrix glycosaminoglycan hyaluronan. CD44 participates in a variety of physiological and pathological processes through its role in cell adhesion. Under appropriate conditions, the ectodomain of CD44 is proteolytically removed from the cell surface. In this study we show t...

OBJECTIVE Cells with unique phenotypes and stem cell-like properties have been found to exist in breast cancer. The aim of the present study was to study the relationship of CD24, CD44, CD44(+)/CD24(-/low) and CD44(-)/CD24(+) tumor phenotypes' with clinico-pathological features, chemotherapy response and with prognosis. METHODS The study included paraffin-embedded tissues of 140 primary and s...

Despite their suggested importance, the mechanistic roles of FGFR2 and gastric cancer stem cell (GCSC) marker CD44 remain unclear. We investigated cross talk between CD44 and FGFR2. FGFR2 and CD44 positively regulate each other's expression. While FGFR2 suppresses c-Myc transcription, CD44 activates it. c-Myc in turn augments FGFR2 transcription. CD44 knockdown (KD) depleted FGFR2 and other GCS...

BACKGROUND CD44 is a cell surface glycoprotein found on many normal cells, mainly lymphoid and epithelial. Normal cells usually express standard CD44 (CD44-S), whereas malignant tumours may express CD44 variant isoforms (CD44-V). CD44 expression has been described for neural crest derivatives. Characterisation of differences in CD44 expression may help in the diagnosis and differentiation of di...