نتایج جستجو برای: ccl22

تعداد نتایج: 1448  

Journal: :Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2009
Martina Sandberg Anne Frykman Jan Ernerudh Göran Berg Leif Matthiesen Christina Ekerfelt Lennart J Nilsson Maria C Jenmalm

Exposure to ubiquitous allergens early in life, even before birth, may influence the incidence of allergic diseases later in life. During pregnancy, the fetomaternal interface is surrounded by high levels of T-helper (Th)2-like cytokines, possibly favouring the development of Th2-like immune responses in the offspring. The aim of this study was to evaluate the relation between cord blood (CB) I...

2016
Jia Sun Jintang Sun Bingfeng Song Lin Zhang Qianqian Shao Yanguo Liu Daoying Yuan Yun Zhang Xun Qu

In tumor microenvironment, macrophages as a polarized M2 population promote tumor progression via releasing multiple cytokines and chemokines. A brown seaweed fucose-rich polysaccharide, fucoidan has antitumor activity and immune modulation through affecting tumor cells and lymphocytes. Here, we focused on the effect of fucoidan on macrophages especially M2 subtype. Our results demonstrated tha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Buvana Ravishankar Rahul Shinde Haiyun Liu Kapil Chaudhary Jillian Bradley Henrique P Lemos Phillip Chandler Masato Tanaka David H Munn Andrew L Mellor Tracy L McGaha

Tolerance to apoptotic cells is essential to prevent inflammatory pathology. Though innate responses are critical for immune suppression, our understanding of early innate immunity driven by apoptosis is lacking. Herein we report apoptotic cells induce expression of the chemokine CCL22 in splenic metallophillic macrophages, which is critical for tolerance. Systemic challenge with apoptotic cell...

Journal: :Journal of immunology 2013
Seema Rawal Fuliang Chu Min Zhang Hyun Jun Park Durga Nattamai Shibichakravarthy Kannan Rakesh Sharma David Delgado Tina Chou Heather Y Lin Veerabhadran Baladandayuthapani Amber Luong Francisco Vega Nathan Fowler Chen Dong R Eric Davis Sattva S Neelapu

The microenvironment of human follicular lymphoma (FL), an incurable B cell non-Hodgkin's lymphoma, is thought to play a major role in its pathogenesis and course. Microenvironmental cells of likely importance include follicular Th cells (TFH) and regulatory T cells (Tregs), and understanding their interactions with FL tumor cells is necessary to develop novel therapeutic strategies. We found t...

Abbas Ghaderi, Abdolrasoul Talaei Faezeh Moghaddasi-Sani Mahboubeh Razmkhah Mohammad Reza Haghshenas Nasrollah Erfani,

Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known to be associated with poor prognosis. Objective: To investigate the association of a single...

2011
Jan Walter Linda Fraga Melanie J Orin William D Decker Theresa Gipps Alice Stek Grace M Aldrovandi

BACKGROUND Pregnant women are at an increased risk for HIV infection due to unknown biological causes. Given the strong effect of sex-hormones on the expression of immunomuodulatory factors, the central role of mucosal immunity in HIV pathogenesis and the lack of previous studies, we here tested for differences in immunomuodulatory factors in cervico-vaginal secretions between pregnant and non-...

Journal: :Journal of immunology 2009
Toshiharu Onodera Myoung Ho Jang Zijin Guo Mikako Yamasaki Takako Hirata Zhongbin Bai Noriko M Tsuji Daisuke Nagakubo Osamu Yoshie Shimon Sakaguchi Osamu Takikawa Masayuki Miyasaka

Dendritic cells (DCs) express the immunoregulatory enzyme IDO in response to certain inflammatory stimuli, but it is unclear whether DCs express this enzyme under steady-state conditions in vivo. In this study, we report that the DCs in mesenteric lymph nodes (MLNs) constitutively express functional IDO, which metabolizes tryptophan to kynurenine. In line with a previous report that regulatory ...

2012
Christine Ménétrier-Caux Julien Faget Cathy Biota Michael Gobert Jean-Yves Blay Christophe Caux

Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production.

2011
Tomomitsu Hirota Hidehisa Saeki Kaori Tomita Shota Tanaka Kouji Ebe Masafumi Sakashita Takechiyo Yamada Shigeharu Fujieda Akihiko Miyatake Satoru Doi Tadao Enomoto Nobuyuki Hizawa Tohru Sakamoto Hironori Masuko Takashi Sasaki Tamotsu Ebihara Masayuki Amagai Hitokazu Esaki Satoshi Takeuchi Masutaka Furue Emiko Noguchi Naoyuki Kamatani Yusuke Nakamura Michiaki Kubo Mayumi Tamari

Atopic dermatitis (AD) is a common inflammatory skin disease caused by multiple genetic and environmental factors. AD is characterized by the local infiltration of T helper type 2 (Th2) cells. Recent clinical studies have shown important roles of the Th2 chemokines, CCL22 and CCL17 in the pathogenesis of AD. To investigate whether polymorphisms of the CCL22 gene affect the susceptibility to AD,...

2016
Fang Liu Xiaoyan Ding Yu Yang Jiaqing Li Miao Tang Miner Yuan Andina Hu Zongyi Zhan Zijing Li Lin Lu

PURPOSE To investigate the chemokine expression profiles in the aqueous humor of wet age-related macular degeneration (wet AMD) patients and to correlate their levels with clinical findings. METHODS Undiluted aqueous humor samples (100-200 μl) were obtained from 16 wet AMD eyes and 12 control eyes. Forty chemokines were measured using a multiplex method. A 6×6 mm area of the macular region ce...

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