Hypoxic exercise exerts a significant effect on body weight loss and fat reduction. Methods: In the present study, we constructed an obese rat model divided rats into following groups: Normoxic quiet (C), (H), Exercise (CE), (HE). We employed isobaric tags for relative absolute quantification (iTRAQ) using proteomic technology to screen differentially expressed proteins in four groups. Addition...

Background & Objective: Basal cell carcinoma (BCC) is a common skin cancer arising from the basal layer of the epidermis and its appendages. They are locally invasive, aggressive, and destructive of skin and the surrounding structures. β-Catenin is a multifunctional protein located to the intracellular side of the cytoplasmic membrane coded by the CTNNB1 gene, which maps to chr...

Abstract Introduction Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG. Methods In vivo, 12-month-old male mice were utilized to evaluate the effect of on bone mass. vitro, marrow stem cells (BMSCs) isolated and extracted from 3-month-old OPG −/− littermates +/+ mice. Calvaria ost...

Background: LGR5 is one of the most important stem cell markers for colorectal cancer (CRC), as it potentiates Wnt/Β-catenin signaling. The well-characterized deregulation signaling that occurs during adenoma/carcinoma sequence in CRC renders a hopeful therapeutic target. We assessed immunohistochemical expression and Β-catenin normal colonic tumorous lesions with clinicopathological correlatio...

Culture of embryonic stem (ES) cells at high density inhibits both beta-catenin signaling and neural differentiation. ES cell density does not influence beta-catenin expression, but a greater proportion of beta-catenin is targeted for degradation in high-density cultures. Moreover, in high-density cultures, beta-catenin is preferentially localized to the membrane further reducing beta-catenin s...

chronic myeloid leukemia (cml) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the philadelphia (ph) chromosome. although imatinib inhibits the bcr-abl kinase activity, clinical experiences confirm that imatinib may not target cml stem cells in vivo. the identification of signaling pathways responsible for the self-renewal properties of leukemic...

Wnt/ -catenin is a neuroprotective pathway regulating cell fate commitment in the CNS and many vital functions of neurons and glia. Its dysregulation is linked to a number of neurodegenerative diseases. Wnt/ -catenin is also a repressor of HIV transcription in multiple cell types, including astrocytes, which are dysregulated in HIV-associated neurocognitive disorder. Given that HIV proteins can...

background: it has been reported that secreted frizzled-related protein-4 known as an antagonist of wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. the purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhsfrp-4) could directly induce terminal differentiation of rat granulosa cells (gcs) and 2)...

Many studies indicate the involvement of WNT signaling in oncogenesis and melanoma drug resistance. Receptor-interacting protein kinase (RIPK4), which targets multiple pathways such as Wnt/β-catenin, NFKB MAPK, is might be a alternative target. This supported by fact that RIPK4 levels are elevated cells compared to normal melanocytes. Since role this regulation pathway remain unknown, we tested...