BACKGROUND The home hemodialysis (HHD) treatment option has been associated with improved patient outcomes compared to in-center hemodialysis (ICHD) programs. What is not quite clear is the influence of patient selection bias on the perceived benefits of HHD. The purpose of this study was to explore the potential benefits of HHD by comparing the admission patterns of HHD patients with a control...

BACKGROUND Specific nutrients like L-arginine (L-Arg) ameliorate intestinal inflammation, however the exact mechanisms of this effect are unclear. We hypothesized the anti-inflammatory effects of L-Arg require active transport and metabolism by inducible nitric oxide synthase (iNOS) to generate nitric oxide (NO). To test this hypothesis we examined the effects of L-Arg, L-Arg transport activity...

Augmenting endothelial specific transport of the nitric oxide precursor L-arginine via cationic amino acid transporter-1 (CAT1) can prevent obesity related hypertension. We tested the hypotheses that CAT1 overexpression prevents obesity-induced hypertension by buffering the influence of the sympathetic nervous system (SNS) on the maintenance of arterial pressure and by buffering pressor respons...

Previous work demonstrated that l-arginine, the substrate for nitric oxide (NO) synthase, is carried into inner medullary collecting duct (IMCD) cells via system y+, that the major system y+ gene product in IMCD is the cationic amino acid transporter 1 (CAT1), and that blockade of l-arginine uptake in the renal medulla decreases NO and leads to systemic hypertension. The present study determine...

Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen species (ROS) is an essential component of these responses. We showed previously that ectopic expression of the heme-containing catalase enzyme in Candida albicans enhances resistance to oxidative stress, combinatoria...

The representation of three-dimensional objects with point clouds is attracting increasing interest from researchers and practitioners. Since this requires a huge data volume, effective cloud compression techniques are required. One the most powerful solutions Moving Picture Experts Group geometry-based (G-PCC) emerging standard. In G-PCC lifting transform coding technique, an adaptive quantiza...