The prevalence of preeclampsia in Colombia is 4.5%2 and a casecontrol study is appropriate to investigate risk and protective factors associated in such setting and their corresponding Odds Ratios. However, in the population studied by Alzate et al, the proportion of preeclampsia is 10% (387/3866 ). Under this scenario, a retrospective cohort study design is also appropriate and allows for dire...

Objective: The objective of the study is to assess protein oxidation status and its correlation with antioxidant potential in serum during preeclampsia (PE). Materials Methods: A casecontrol was performed on 63 pregnant subjects (mean age = 30 tential serpreeclamptic 32 age-matched normotensive (control) women. Serum samples were analyzed for total protein, globulin, albumin, carbonyls (PCO), a...

The association between hormone replacement therapy (HRT) and venous thromboembolism (VTE) was matter of discussion until ’90 years. Although an increased incidence of thrombotic events has been always described in population taking HRT, several reports did not find significant association between both conditions until 1996 [3, 4]. However, beginning from 1996 most and most Authors found a sign...

Individual participant time-to-event data from multiple prospective epidemiologic studies enable detailed investigation into the predictive ability of risk models. Here we address the challenges in appropriately combining such information across studies. Methods are exemplified by analyses of log C-reactive protein and conventional risk factors for coronary heart disease in the Emerging Risk Fa...

Objective: To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx. Methods: We present a narrative literature review, conducted in Pubmed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk ...

An elevated risk of lung cancer associated with lower levels of body mass index (BMI) has been reported in previous studies.1-9 However, the interpretation of the association between low BMI and lung cancer is complicated by the fact that weight loss may be a sign of smoking. In general, smokers tend to be lighter than non-smokers,1, 10-15 and it is believed that nicotine is responsible for the...