In Situ Cartilage Repair article 2201588 by Xiong Shu, Sujun Wu, Juan Guan, and co-workers, a cell-free silk protein sponge is fitted on site of cartilage defect. The in situ repair assisted programmed factors E7 TGF-β1, that trigger serial events autologous stem cell homing, directed differentiation chondrocyte proliferation.

Osteoarthritis leads to the progressive decay of articular cartilage. Due its intrinsic avascular character, cartilage shows an inadequate capacity for regeneration. Cartilage loss may result in chronic pain, movement disorder and morbidity, which lack effective treatments except joint replacement late-stage osteoarthritis. To overcome this challenge, tissue engineering has emerged as a promisi...

Hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. After some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. Currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. In this regard, tissue&...

introduction: the aim of this study was to differentiate human mesenchymal stem cells (hmscs) into cartilage in a micromass culture system and study of their structure by light and electron microscopy. material and methods: human bone marrow cells obtained from volunteer patients were plated in 75-cm2 flasks and their mscs were expanded through several sub-cultures. the passage 4 cells were use...

Endochondral ossification begins from the condensation and differentiation of mesenchymal cells into cartilage. The cartilage then goes through a program of cell proliferation, hypertrophic differentiation, calcification, apoptosis, and eventually is replaced by bone. Unlike most cartilage, articular cartilage is arrested before terminal hypertrophic differentiation. In this study, we showed th...

Objective Articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. On the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. Little is known about the presence of mesenchymal stem cells in articular cartilage tissue. This subject is investigated in the present study. Materials and Methods Artic...

Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to loss of joint function. The molecular mechanisms regulating pathogenesis and progression of osteoarthritis are poorly understood. Remarkably, some characteristics of this joint disease resemble chondrocyte differentiation processes during skeletal development by endochondral ossification. In healthy a...

We have successfully fabricated the cartilage/natural rubber latex (NRL) biocomposites via human mesenchymal stem cells (hMSCs) spheroid under hypoxic condition. It was revealed that NRL nanoparticles acted as main component, providing surface heterogeneity for spheroids and resulting in a mechanically stable structure with modulus two times higher compared to controls. The formation of cartila...

objective: finding cell sources for cartilage tissue engineering is a critical procedure. the purpose of the present experimental study was to test the in vitro efficacy of the beta-tricalcium phosphate-alginate-gelatin (btag) scaffold to induce chondrogenic differentiation of human umbilical cord blood-derived unrestricted somatic stem cells (usscs). materials and methods: in this experimental...