The frequency-response curve of isolated canine arterial segments at transmural pressures between 140 and 40 mm Hg showed an initial constant-amplitude portion over the lower frequency range followed by one or two major amplitude peaks (resonances) at higher frequencies. At lower transmural pressures, the response was more damped and resonances were infrequent. The amplitude of the flat portion...

BACKGROUND Decreased arterial elasticity is a risk factor for several cardiovascular outcomes. Longitudinal data on the effect of physical activity in youth on adult arterial elasticity are limited. The aim of this study was to determine the long-term effects of physical activity in children and young adults on carotid artery elasticity after 21 years of follow-up. METHODS AND RESULTS Partici...

BACKGROUND AND PURPOSE Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. METHODS The ongoing Northern Manhattan Family Study recruits high-risk Caribbean Hispanic families t...

Background and Purpose—Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. Methods—The ongoing Northern Manhattan Family Study recruits high-risk Caribbean Hispanic families to ...

BACKGROUND Physical activity reduces the risk of vascular disease. This benefit is not entirely explained through an effect on vascular risk factors. We examined the relationship of physical activity and characteristics of the carotid artery wall in patients with vascular disease or risk factors. METHODS AND RESULTS Cross-sectional analyses were performed in 9578 patients from the SMART (Seco...

background substrates in medical science are hydrophilic polymers undergoing volume expansion when exposed to culture medium that influenced on cell attachment. although crosslinking by chemical agents could reduce water uptake and promote mechanical properties, these networks would release crosslinking agents. in order to overcome this weakness, silicone rubber is used and reinforced by nanocl...

BACKGROUND Antihypertensive drugs may have differential, pressure-independent effects on hypertension-associated alterations of arterial function. We compared the effects of a 12-week therapy with the AT(1)-receptor antagonist valsartan (Val) versus the beta-blocker metoprolol (Met) on arterial stiffness and endothelial function in mildly hypertensive patients at rest and during generalized sym...

Associations with antihypertensive medication classes and progression of arterial stiffness have not been studied in a prospective multiethnic cohort. All participants had hypertension at baseline, defined as blood pressure ≥140/90 mm Hg or use of antihypertensive medications. Medication use and blood pressure were assessed at 5 time points. Young's elastic modulus and distensibility coefficien...

As cardiovascular death remains major cause of death worldwide , there are growing needs for risk evaluation for cardiovas-cular event. Arterial stiffness, which refers to the rigidity of arterial wall, increases in the elderly person as well as patients with atherosclerotic disease. Based on the belief that increased vascular stiffness precedes atherosclerotic vascular event, there were attemp...

AIM We investigated the relationship between coronary risk factors and the intima-media thickness (IMT) and wall elasticity of carotid arteries. A new real-time ultrasonic measurement system that allows measurement of the elasticity of the carotid arterial intima-media complex was applied to 350 subjects, who were also checked for the presence/absence of hypertension, dyslipidemia, diabetes mel...