BACKGROUND Oxidative stress plays a crucial role in the development of drug induced nephrotoxicity. The study aimed to determine the nephroprotective and ameliorative effects of Carica papaya seed extract in paracetamol-induced nephrotoxicity in rats. OBJECTIVES To carry out phytochemical screening of Carica papaya, measure serum urea, creatinine and uric acid and describe the histopathologic...

Purpose: To investigate the interacting effects of co-administration of Carica papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model. Method: Experimental factorial design was used to evaluate the individual and interaction influence of three variables ie nature (N), dose administered (C) and duration of administration (D), in a 2(=8) employed at two l...

Among the most important tropical fruit grown in the world today and in Brazil, papaya occupies a prominent place. Native to tropical America, papaya has spread to several regions of the world, and Brazil accounts for 12.74% of the world production, followed by Mexico, Nigeria and India. The culture reached a harvested area of 441,042 ha and production of 12,420,585 t worldwide. The largest int...

This paper aims at reviewing Carica papaya as potential natural medicinal source. Several studies on methods used in extracting Carica papaya materials from different parts of the plant were highlighted. Extracts from different parts of Carica papaya plant have shown protective effects against many diseases such as intestinal worms infection and different types of wounds. Extracts also showed p...

AIM To assess the contraceptive efficacy of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkeys. METHODS The test substance was given p.o. to five monkeys at 50 mg/kg body weight/day for 360 days. Control animals (n=3) received olive oil as vehicle. Sperm parameters as per World Health Organization standards, sperm functional tests, m...

We investigated the antiplasmodial properties of crude extracts from Carica papaya leaves to trace the activity through bioassay-guided fractionation. The greatest antiplasmodial activity was observed in the ethyl acetate crude extract. C. papaya showed a high selectivity for P. falciparum against CHO cells with a selectivity index of 249.25 and 185.37 in the chloroquine-sensitive D10 and chlor...

Thrombocytopenia is a disorder in which there is a thrombocyte count of less than 150×103/μL. Thrombocytopenia is life threatening in many diseases particularly in dengue which is an escalating problem in the world. There was an outbreak of dengue in 2011 in Lahore, Pakistan and it was public opinion that Carica papaya leaf extract helps in recovery of platelet count. The aim of present study w...

Carica papaya belonging to the Caricaceae family is an effective medicinal herb that is used as a folk medicine for the treatment of various diseases throughout the world including Bangladesh. It can be used for treatment of a numerous diseases like warts, corns, sinuses, eczema, cutaneous tubercles, glandular tumors, blood pressure, dyspepsia, constipation, amenorrhoea, general debility, expel...

Ethanolic extracts of Canarium schweinfurthii stem bark and Senna alata leaf, and aqueous extract of unripe Carica papaya fruit, at two different doses (150, 400 mg/kg), were evaluated for antihyperglycaemic and hypolipidemic effects on alloxan-induced diabetic rats following daily oral administration for 28 days. While antihyperglycaemic effect was lacking in Senna alata, it was persistent (P<...

1. Home Cure for Dengue Death Sting. Available from: http:/ /articles.timesofindia. indiatimes.com/2012-09-12/ kolkata/33788187_1_platelet-dengue-patients-papaya. Accessed October 22, 2013 2. Otsuki N, Dang N H, Kumagai E, Kondo A, Iwata S, Morimoto C. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacology. 2010;127:760-7. 3. Ranas...