OBJECTIVES Although elevated cardiac troponin T is caused by myocardial damage in the vast majority of the cases (primary cardiac causes), noncardiac disease with secondary damage to the myocardium (secondary cardiac causes) is being increasingly recognised. The present study aimed to retrospectively evaluate the frequency of primary cardiac and secondary cardiac causes of troponin-T positivity...

Objective: Exercise and nutrition as life style modification strategies for the prevention and control of diabetes are considered. The aim of present study was to assess the effects of saffron consumption and aerobic exercises on serum levels of Heart-type fatty acid binding protein (HFABP) and Troponin T in type2 diabetes (T2DM) patients. Materials and Methods: This study was a quasi-experime...

BACKGROUND Diagnosis of acute myocardial infarction relies upon the clinical history, interpretation of the electrocardiogram, and measurement of serum levels of cardiac enzymes. Newer biochemical markers of myocardial injury, such as cardiac troponin I and cardiac troponin T, are now being used instead of or along with the standard markers, the MB isoenzyme of creatine kinase (CK-MB) and lacta...

Troponin I is the inhibitory component of troponin, the thin filament regulatory complex in striated muscle. Separate genes encode cardiac-specific fast and slow skeletal-specific isoforms of this protein. We have previously described gene switching from the slow skeletal to the cardiac troponin I mRNA expression in developing rat heart. The purpose of this work was to characterize the expressi...

Troponin I is a subunit of the thin filament-associated troponin-tropomyosin complex involved in calcium regulation of skeletal and cardiac muscle contraction. We deleted the cardiac isoform of troponin I by using gene targeting in murine embryonic stem cells to determine the developmental and physiological effects of the absence of this regulatory protein. Mice lacking cardiac troponin I were ...

BACKGROUND Elevations of cardiac enzymes are commonly used to indicate myocardial ischemia, but they can be elevated due to other conditions. Different forms of Troponin (cTnT, sTnT, cTnI), can cause cross-reactivity in the Troponin T assay, leading to false positives. This report describes a patient with polymyositis who had elevated Troponin T, but no cardiac abnormalities. The purpose is to ...

BACKGROUND New-generation high-sensitivity assays for cardiac troponin have lower detection limits and less imprecision than earlier assays. Reference 99th-percentile cutoff values for these new assays are also lower, leading to higher frequencies of positive test results. When cardiac troponin concentrations are minimally increased, serial testing allows discrimination of myocardial infarction...

OBJECTIVE The objective is to verify the cardiac troponin I values in children less than 1 year of age without clinical cardiac dysfunction. METHODS The cardiac troponin I values were determined in 99 children less than 1 year of age, including term infants without diseases related to cardiac dysfunction using the specific kit Opus T Troponin I (cTn) (Dade Behring Inc. -Newalk, DE 19714, USA)...