نتایج جستجو برای: cardiac iron overload
تعداد نتایج: 430331 فیلتر نتایج به سال:
Background In patients with myelodysplastic syndrome (MDS) no longitudinal studies on cardiac iron, function and fibrosis are available in literature. So, the aim of our study was to assess the changes in cardiac iron overload and in the morpho-functional cardiac parameters by Magnetic Resonance Imaging (MRI) in MDS patients enrolled in the MIOMED (Myocardial Iron Overload in MyElodysplastic Di...
BACKGROUND Abnormal iron deposition may cause oxidant-induced damage in various organs. We have previously reported that continuous administration of angiotensin II to rats results in an overt iron deposition in the renal tubular epithelial cells, which may have a role in angiotensin II-induced renal damage. In the present study, we investigated the role of iron in the development of cardiac in...
The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in transfusional iron overload, strongly indicates that iron accumulation in the heart plays a major role in the process leading to heart failure. In this context, iron-mediated generation of noxious reactive oxygen species is believed to be the most important pathogenetic mechanism determining cardiomyocyte damag...
| 1096 | haematologica | 2008; 93(7) In conclusion, in never or minimally transfused patients with thalassemia intermedia we found no evidence of cardiac iron overload, while there may be significant hepatic iron accumulation. However, since cardiac MRI has not been routinely used in TI, further studies and longer follow-up are needed to understand if and when detectable cardiac iron deposition...
Review Article Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms
The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in transfusional iron overload, strongly indicates that iron accumulation in the heart plays a major role in the process leading to heart failure. In this context, ironmediated generation of noxious reactive oxygen species is believed to be the most important pathogenetic mechanism determining cardiomyocyte damage...
The risk and clinical significance of cardiac iron overload due to chronic transfusion varies with the underlying disease. Cardiac iron overload shortens the life expectancy of patients with thalassemia, whereas its effect is unclear in those with myelodysplastic syndromes (MDS). In patients with sickle cell anemia (SCA), iron does not seem to deposit quickly in the heart. Our primary objective...
Recent advances in magnetic resonance imaging (MRI) techniques allow the assessment of iron overload in tissues 1 especially the heart, 2 in transfusion-dependent thalassemia patients. The R2* value (1/T2*) recorded in the intraventricular septum of the heart indirectly measures the degree of cardiac iron load. Applying this new technology we looked at a number of historical and biochemical par...
To report a case of iron overload secondary to xerocytosis, a rare disease in a teenager, diagnosed, by T2* magnetic resonance imaging. We report the case of a symptomatic patient with xerocytosis, a ferritin level of 350ng/mL and a significant cardiac iron overload. She was diagnosed by T2* magnetic resonance imaging and received chelation therapy Ektacytometric analysis confirmed the diagnosi...
Background Sickle-thalassemia is an inherited hemoglobin disorder resulting from the combined heterozygosity for sicklecell and b-thalassemia genes. Myocardial iron overload in patients with sickle-thalassemia has been poorly studied; however, a report has shown no evidence of cardiac iron in a small group (n=10) of multitransfused Arab patients. The current study aims to further evaluate cardi...
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