The Effect of Calcium and Sodium Ion on the Frequency-Force Relationship in Cardiac Muscle. DAVID 0. TEIGER AND ALFRED FARAH 1 The Uptake and Binding of Six Radiolabeled Cardiac Glycosides by Guinea-Pig Hearts and by Isolated Sarcoplasmic Reticulum. S. DUTTA, S. Gosw u, D. K. DATrA, J. 0. LINDOWER AND B. H. MARKS 10 The Effects of Cardiac Glycosides and Their Interaction with Catecholamines on ...

The therapeutic effect of cardiac glycosides for congestive heart failure lies in their reversible inhibition on Na+, K+-ATPase located in human myocardium. Several steroid-like compounds containing a core structure similar to cardiac glycosides have been found in many Chinese herbs and medicinal animal products conventionally used to promote blood circulation. They are putatively responsible f...

Using microelectrodes having an external diameter of less than 1 ,u, potential variations of single caidiac fibers were obtained from frog ventriculai' muscle in situ. The normal membrane potential consists of a rapid depolarization and slow reecovery, the latter occurring in three distinct phases. Digitalis glycosides alter profoundly the slopes of these various phases and dlastically shorten ...

author offers no evidence to support his own contentions other than "laboratory studies show," "phylobiological investigations show," "my researches and those of my associates show." A really specific account of the therapeutic method to be used, or how the physiological method is to be applied, is found nowhere in the book, nor are any concrete case histories supplied. A much-needed glossary, ...

Strophanthus (Family apocynaceae) contains glycosides which are comparable with cardiac glycosides of Digitalis but has less harmful physiological actions, S. kombe Oliver is officially used but some other species of this genus also contain glycosides and resemble the official one and thus often used as adulterants, This study shows distinguishing features of some strophanthus species.

Cardiac glycosides are well known in the treatment of cardiovascular diseases; however, their application as treatment option for cancer patients is under discussion. We showed that the cardiac glycoside digitoxin and its analog AMANTADIG can inhibit the growth of renal cell carcinoma (RCC) cell lines and increase G2/M cell cycle arrest. To identify the signaling pathways and molecular basis of...

Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na+/K+ ATPase (NKA), which raises [Na+]i and attenuates Ca2+ extrusion via the Na+/Ca2+ exchanger (NCX), causing [Ca2+]i elevation. The resulting [Ca2+]i accumulation further enhances Ca2+-induced Ca2+ release, generating the positive inotropic effect. However, cardiac glycosides hav...

The present study deals with the cytotoxic activity of cardiac glycosides of Calotropis gigantea (L.) W.T.Aiton; on breast cancer cell line MCF-7. Qualitative screening of methenaloic extract of leaves of Calotropis gigantea for secondary metabolites showed the presence of phenolics, alkaloids, coumarins, saponins, tannins and glycosides. Glycosides were selected for detailed chemical analysis,...

Cardiac glycosides could increase intracellular Ca2+ ion by inhibiting the Na+/K+ATPase to induce apoptosis in many tumor cells. However, narrow therapeutic index, poor tumor selectivity and severe cardiovascular toxicity hinder their applications in cancer treatment. To improve the safety profile and tumor targetablility of cardiac glycosides, we designed octreotide conjugated periplocymarin, ...

Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body. Congestive heart failure is characterized by ...