OBJECTIVES The objective of this study was to elucidate the safety and effectiveness of acemannan, a polysaccharide extracted from Aloe vera, in the treatment of oral aphthous ulceration. DESIGN A skin patch test was performed on 100 healthy subjects, and 0.5% acemannan in Carbopol® 934P NF (Lubrizol Corporation, USA) was applied to the oral mucosa of the lower lip of 50 healthy participants ...

Buccoadhesive tablets of Metclopramide Hydrochloride were fabricated with objective of avoiding extensive first pass metabolism and to prolong its duration of action with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Chitosan, HPMC K4M and HPMC K15M. Tablets were prepared by direct compression method using polymer in different ratios. The ...

The present study outlines a systematic approach for designing and development of Ofloxacin floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Ofloxacin have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Floating tablets of Of...

Famotidine has been the most widely used drug for the treatment of peptic ulcer for many decades. The present investigation concerns the development and evaluation of floating tablets of famotidine which, after oral administration, are designed to prolong the gastric residence time, increase drug bioavailability and target the gastric ulcer. A floating drug delivery system (FDDS) was developed ...

The influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. For this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of Carbopol 934P, 971P, 974P, Pemulen and Eudragit RLPO as retarding agents and inactive ingredients (e.g. PVP, Avicel or ...

the influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. for this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of carbopol 934p, 971p, 974p, pemulen and eudragit rlpo as retarding agents and inactive ingredients (e.g. pvp, avicel or ...

Drug delivery via buccal mucosa by means of buccoadhesive formulations offer distinct advantages over peroral administration. Recently, plant gums and exudates have been screened for their use as pharmaceutical adjuvants. The aim of this study is to evaluate matrix tablets containing Plantago psyllium seed mucilage in addition to carbopol as a mucoadhesive agent, and propranolol hydrochloride a...

the purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. a 32 full factorial design was employed to study the effect of independent variables like carbopol-934p and hydroxypropyl methylcellulose k100m, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...

drug delivery via buccal mucosa by means of buccoadhesive formulations offer distinct advantages over peroral administration. recently, plant gums and exudates have been screened for their use as pharmaceutical adjuvants. the aim of this study is to evaluate matrix tablets containing plantago psyllium seed mucilage in addition to carbopol as a mucoadhesive agent, and propranolol hydrochloride a...

The influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. For this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of Carbopol 934P, 971P, 974P, Pemulen and Eudragit RLPO as retarding agents and inactive ingredients (e.g. PVP, Avicel or ...