Purpose: The objective of this study was to prepare Propranolol Hydrochloride controlled release matrix tablets and to investigate the effect of the polymer blends and the polymer concentration on drug release. Method: Propranolol Hydrochloride controlled release matrix tablets were prepared by direct compression technique. Hydroxypropylmethylcellulose K15M (HPMC K15M) and Carbopol 934P were us...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Purpose: To prepare and evaluate metformin microspheres for prolonged release. Methods: Metformin microspheres were prepared by non-aqueous solvent evaporation method using various polymers, including ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC), carbopol 934P (CA) and chitosan (CH). The effect of process variables, viz, drug/polymer ratio, stirring rate and type of polymer on the ...

OBJECTIVES The purpose of this study was to characterize commercial glass polyalkenoate cement (GPC) or glass ionomer cement (GIC), Glass Carbomer(®), which is designed to promote remineralization to fluorapatite (FAp) in the mouth. The setting reaction of the cement was followed using magic angle spinning nuclear magnetic resonance (MAS-NMR) spectroscopy. METHODS Glass Carbomer(®) initial gl...

The objective of the present investigation is to formulate Nizatidine loaded superporous floating hydrogel tablets. In the present study Nizatidine floating tablets were prepared by effervescence method using sodium bicarbonate as a gas generating agent. The tablets were formulated using direct compression technology by employing polymers like chitosan, carbopol 934p and ethyl cellulose. The pr...

Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as hydroxypropylmethylcellulose K4M, carbopol 934P, and sodium alginate, either a...

Aim: The aim of the work was to explore mucoadhesive properties Mastic gum by involving it in microspheres with Amoxicillin Trihydrate as a model drug. Using Carbopol-934P and varying amounts gum. Methods: 9 interpretations were made using Design expert software. A central composite design applied test impact independent variables (Carbopol-934P mastic levels) on drug released at 10h strength r...

background the goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability. material and methods to select the best formulation, formulations with different concentration of carbomer and hpmc were evaluated for their appearance. then evaluated for physicochemical characteristics such as rheologic behavior...

Using a strain-controlled rheometer, rhelogical characterization of carbopol 940 has been made in steady shear and start-up flow fields. In this study, aqueous carbopol 940 solutions with different concentrations were used to provide a fundamental information in application of pharmaceutical and cosmetic areas.

Abstract: Objectives: The ambition of this study is to find the mucoadhesive assets Pistacia lentiscus plant gum (mastic gum) by combining it into microspheres with Amoxicillin Trihydrate (ATH). Significance: Due its short stomach residence duration, ATH efficient against H. pylori but can be improved creating Mucoadhesive Microspheres (MMS) that keep trihydrate in stomach. In study, has been e...