This review provides a short account of the chemical synthesis nucleoside di- and triphosphates on historical background, together with use this class compounds as potential pronucleotides in anti-HIV therapy.

Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and no CNT2-dependent nucleoside uptake was observed, while rat hepatocytes exhibited high CNT2-depen...

This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized ...

Nucleoside analogues have proven to be a highly successful class of anti-cancer and anti-viral drugs. The therapeutic efficacy of nucleoside analogues is dependent of their intracellular phosphorylation. Two cellular nucleoside kinases, deoxycytidine kinase (dCK) and UMP-CMP kinase (CMK) are critical for phosphorylation of cytidine analogues. These kinases provide two first steps of activation ...

With the discovery of ATP structure in 1929, significant progress was made understanding role nucleosides and nucleotides body. One most important breakthroughs is associated with determination function an autacoid ATP, a participant purinergic signal transmission. For first time, this pointed out by Professor Geoffrey Burnstock 1972. Purinergic signaling activators are extracellular including ...

Nucleoside analogs used in cancer chemotherapy and in treatment of virus infections are phosphorylated in cells by nucleoside and nucleotide kinases to their pharmacologically active form. The phosphorylated nucleoside analogs are incorporated into DNA and cause cell death or inhibit viral replication. Cellular DNA is replicated both in the nucleus and in the mitochondria, and nucleoside analog...

Addition of the nucleoside diphosphates CDP, UDP, TDP, and IDP to intact, respiring, rat liver mitochondria immediately following ATP formation results in a marked stimulation of respiration at all concentrations of nucleotide tested. Addition of GDP stimulates respiration when added at concentrations below 150 PM, whereas at higher concentrations this nucleotide has much less effect on respira...