HASSAN A ALHAZMI, HAFIZ A MAKEEN, SAMI EL DEEB Department of Pharmaceutical Chemistry, College of pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia. Department of Clinical Pharmacy, College of pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia. Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany Department of Pharmaceutical Chemistry, Al-Azhar Uni...

Capillary electrophoresis provides very high efficiency separations of biological molecules. Laser-induced fluorescence produces very high sensitivity detection. The combination of the two techniques results in an analytical tool with unprecedented properties: separations with more than a million theoretical plates and detection limits of a few hundred analyte molecules. This paper considers th...

CIEF and CZE are coupled with LIF detection to create an ultrasensitive 2-D separation method for proteins. In this method, two capillaries are joined through a buffer-filled interface. Separate power supplies control the potential at the injection end of the first capillary and at the interface; the detector is held at ground potential. Proteins are labeled with the fluorogenic reagent Chromeo...

Many researchers have invested considerable efforts toward improving capillary electrophoresis (CE)-mass spectrometry (MS) systems so they can be applied better to standard analyses. This review highlights the developments in CE-MS of proteins and peptides over the last five years. It includes the developments in interfaces, sample-enrichment techniques, microfabricated devices, and some applic...