Hub networks have always been acriticalissue in locating health facilities. Recently, a study has been investigated by Cocking et al. (2006)in Nouna health district in Burkina Faso, Africa, with a population of approximately 275,000 people living in 290 villages served by 23 health facilities. The travel times of the population to health services become extremely high during the rainy season, s...

in this paper, we study the problem of integrated capacitated hub location problem and seat inventory control considering concept and techniques of revenue management. we consider an airline company maximizes its revenue by utilizing the best network topology and providing proper booking limits for all itineraries and fare classes. the transportation system arises in the form of a star/star net...

Capacitated versions of Vertex Cover and Dominating Set have been studied intensively in terms of polynomial time approximation algorithms. Although the problems Dominating Set and Vertex Cover have been subjected to considerable scrutiny in the parameterized complexity world, this is not true for their capacitated versions. Here we make an attempt to understand the behavior of the problems Cap...

a novel algorithm for the fast detection of hubs in chemical networks is presented. thealgorithm identifies a set of nodes in the network as most significant, aimed to be the mosteffective points of distribution for fast, widespread coverage throughout the system. we showthat our hubs have in general greater closeness centrality and betweenness centrality thanvertices with maximal degree, while...

BACKGROUND It has been recognized that modular organization pervades biological complexity. Based on network analysis, 'party hubs' and 'date hubs' were proposed to understand the basic principle of module organization of biomolecular networks. However, recent study on hubs has suggested that there is no clear evidence for coexistence of 'party hubs' and 'date hubs'. Thus, an open question has ...

Intrinsic disorder and distributed surface charge have been previously identified as some of the characteristics that differentiate hubs (proteins with a large number of interactions) from non-hubs in protein-protein interaction networks. In this study, we investigated the differences in the quantity, diversity, and functional nature of Pfam domains, and their relationship with intrinsic disord...

When averaged over the full yeast protein-protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-wide analysis of protein evolution in the subnetworks of associations involving yeast transcription factors (TFs) reveals that TF hubs do not ...

Human brain structural networks contain sets of centrally embedded hub regions that enable efficient information communication. However, it remains largely unknown about categories of structural brain hubs and their microstructural, functional and cognitive characteristics as well as contributions to individual identification. Here, we employed three multi-modal imaging data sets with structura...