breathomics is the metabolomics study of exhaled air. it is a powerful emerging metabolomics research field that mainly focuses onhealth-related volatile organic compounds (vocs). since the quantity of these compounds varies with health status, breathomics assuresto deliver noninvasive diagnostic tools. thus, the main aim of breathomics is to discover patterns of vocs related to abnormal metabo...

abstractintroduction: cancer is caused by genetic abnormalities, such as mutation of ontogenesis or tumor suppressor genes which alter downstream signaling pathways and protein-protein interactions. comparison of protein interactions in cancerous and normal cells can be of help in mechanisms of disease diagnoses and treatments. methods: we constructed protein interaction networks of cancerous a...

Genomic alterations lead to cancer complexity and form a major hurdle for comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe recent advances in studying cancer-associated genes from a systems biology point of view. The integration of known cancer genes onto protein and signaling networks reveals the characteristics of cancer genes within ...

Breast cancer is the most common cancer among women and the earlier it is diagnosed, the easier it is to treat. The most common way to diagnose breast cancer is mammography. Mammography is a simple chest x-ray and a tool for early detection of non-palpable breast cancers and tumors. However, due to some limitations of this method such as low sensitivity especially in dense breasts, other method...

Epithelial-to-Mesenchymal Transition (EMT) plays a key role in epithelial-cancer. The state trajectory of its underlying Gene Regulatory Network (GRN) includes three fixed-point attractors characterizing epithelial, senescent, and mesenchymal, cell phenotypes, which implies specific cell-to-cell cell-to-tissue interactions. interplay between the GRN driving EMT one regulating Mammalian Cell Cyc...