Deoxynivalenol (DON), the mycotoxin produced mainly by Fusarium graminearum and found in contaminated cereal-based foodstuff, has been consistently detected in body fluids in adults. Available data in children and adolescents are scarce. This study assessed urinary DON concentrations in children aged 3-9 years (n = 40) and adolescents aged 10-17 years (n = 39) in the UK. Morning urine samples w...

Deoxynivalenol (DON) is the most prevalent trichothecene in Europe and its occurrence is associated with infections of Fusarium graminearum and F. culmorum, causal agents of Fusarium head blight (FHB) on wheat. Resistance to FHB is a complex character and high variability occurs in the relationship between DON content and FHB incidence. DON conjugation to glucose (DON-3-glucoside, D3G) is the p...

Biomin BBSH 797, a Gen. nov. sp. nov. of the family Coriobateriaceae isolated from bovine rumen fluid, is able to specifically detoxify trichothecenes in the intestinal tract of animals. The live strain is able to produce enzymes that reduce the epoxide group of these mycotoxins, which results in the formation of non-toxic metabolites. The objective of this trial was to prove that the metabolit...

Faixová Z, Š. Faix, R. Bořutová, Ľ. Leng: Effi cacy of Dietary Selenium to Counteract Toxicity of Deoxynivalenol in Growing Broiler Chickens. Acta Vet. Brno 2007, 76: 349-356. The aim of this study was to evaluate the effect of deoxynivalenol on plasma indicators and effi cacy of dietary selenium to counteract toxicity of deoxynivalenol in growing broiler chicks. Three groups of broilers were f...

AbstractThe occurrence of deoxynivalenol (DON) in retail foods in Tehran (Iran) was determined using high-performance liquid chromatography technique and immunoaffinity column as the clean-up step. A method was validated for analysis of DON in rice, bread, puffed corn snack and wheat flour. The average recoveries and precision (RSD) for DON in different foods ranged 84.2-93.1% and 2.9-12.0%, re...

A total of 65 maize grain samples , from 7 maize producing areas of Pakistan, were assayed for 14 toxicologically significant mycotoxins viz., aflatoxin B1 (AfB1), aflatoxin B2 (AfB2), aflatoxin G1 (AfG1), aflatoxin G2 (AfG2), zearalenone (ZON), deoxynivalenol (DON), 3acetyl-deoxynivalenol (3A-DON), 15acetyl-deoxynivalenol (15A-DON), nivalenol (NIV), T-2 toxin (T-2), HT-2 toxin (HT-2), diacetox...

The study determined the occurrence of deoxynivalenol (DON), zearalenone (ZEN) and their metabolites in staple cereals from Southwest Nigeria. Sixty composite samples maize, sorghum millet were evaluated for DON, ZEN masked forms; 3-acetyldeoxynivalenol (3Ac-DON), 15-acetyldeoxynivalenol (15Ac-DON), ?-zearalenone (?-ZEL) ?-zearalenone (?-ZEL). Deoxynivalenol did not co-occur with contrast to pr...

Enzyme-linked immunosorbent assays (ELISAs) are often employed for the control of deoxynivalenol (DON) in barley and other intermediates involved in beer production chain. Because of the occurrence of high levels of DON-3-glucoside (DON-3-Glc) in malt and beer that have been reported for the first time in our earlier study, research focused on the accuracy of DON determination by immunoassays i...

The biosynthesis of mycotoxin deoxynivalenol (DON) in Fusarium graminearum is regulated by two pathway-specific transcription factors Tri6 and Tri10 and affected by various host and environmental factors. In this study, we showed that cyclic adenosine monophosphate (cAMP) treatment induced DON production by stimulating TRI gene expression and DON-associated cellular differentiation in F. gramin...