The contractile and enzymatic activities of myosin VI are regulated by calcium binding to associated calmodulin (CaM) light chains. We have used transient phosphorescence anisotropy to monitor the microsecond rotational dynamics of erythrosin-iodoacetamide-labeled actin with strongly bound myosin VI (MVI) and to evaluate the effect of MVI-bound CaM light chain on actin filament dynamics. MVI bi...

A CAD/CAM system for manufacturing custom seating inserts was evaluated within a moderately to severely disabled population. Using the Otto Bock Shape System, 25 CAD/CAM seats were manufactured at a remote facility and compared to 9 seats manufactured using hard-sculpting techniques. Clinician and client questionnaires were completed for each seat to assess satisfaction, fitting/manufacturing t...

In this paper natural convection heat transfer within a two-dimensional, horizontal, concentric cam shape cylinders that is partially filled with a fluid saturated porous medium has been investigated. both cylinder are kept at constant and uniform temperatures with the outer cylinder being subjected relatively lower than the inner one. In addition the forchheimer and brinkman effect are taken i...

BACKGROUND: Student views of new curricula can shape training outcomes. This qualitative study elicited student opinions of CAM instruction to examine and distill best strategies. METHODS: 49 second, third and fourth year students participated in focus groups using a predefined question route. Interviews were audio taped and transcribed. RESULTS: Students successfully differentiated CAM curricu...

Background Portugal has a strong tradition of conventional western healthcare. So it provides a natural case study for the relationship between Complementary/Alternative Medicine (CAM) and Western Medicine (WM). This work aims to test the relationship between CAM and WM users in the diagnosis and treatment stages and to estimate the determinants of CAM choice.   Methods The forth Portuguese Nat...

Complementary and Alternative Medicine (CAM) is frequently used in Portugal and it contributes to the improvement of people’s health. CAM and Western Medicine (WM) are taken as complements both in the diagnosis and the treatment stage. The Portuguese health system is able to generate certified CAM professionals but the provision of CAM care and services is not included in the national health sy...

A set of design criteria for sensing the shape of an above-knee (AK) stump is presented and used as the basis for evaluating various shape sensing technologies. A mechanical probe type shape sensing system is described and its use in quantifying the external shape of the AK stump is discussed as it relates to generating a grid for finite element analysis in CAD/CAM studies and comparing the seg...

CAM therapies have become increasingly  popular in pediatric populations. phytotherapy are the most common CAM used in children. Yet, little is known about children’s preferences for CAM. But It is expected to become more widely integrated into the modern medical system, including the medical curriculum.The aim of this study is to introduce the prevalence and characteristics of CAM use in Pedia...

Molecular dynamics studies of the N-domain (amino acids 1-77; CaM(1-77)) of Ca2+-loaded calmodulin (CaM) show that a solvent exposed hydrophobic cleft in the crystal structure of CaM exhibits transitions from an exposed (open) to a buried (closed) state over a time scale of nanoseconds. As a consequence of burying the hydrophobic cleft, the R(g) of the protein is reduced by 1.5 A. Based on this...