نتایج جستجو برای: calcium promoter

تعداد نتایج: 255296  

Journal: :Molecular endocrinology 1998
J Weck P C Fallest L K Pitt M A Shupnik

Gonadotropin secretion and gene expression are differentially regulated by hypothalamic GnRH pulses by unknown mechanisms. GnRH stimulates calcium influx through L-type voltage-gated channels and activates phospholipase C, leading to increased protein kinase C (PKC) and mitogen-activated protein kinase activity. We found differential contributions of these pathways to GnRH-stimulated rat LH sub...

The Fischer-Tropsch synthesis (FTS) has been recognized as a heterogeneous surface-catalyzed polymerization process. During this process, CHx monomers formed via the hydrogenation of adsorbed CO on transition metals produce hydrocarbons and oxygenates with a broad range of chain lengths and functional groups. A series of Fe/Cu Fischer-Tropsch synthesis catalysts incorporated with a calcium prom...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
Lydia Barré Narayanan Venkatesan Jacques Magdalou Patrick Netter Sylvie Fournel-Gigleux Mohamed Ouzzine

The importance of heparan- and chondroitin-sulfate proteoglycans in physiological and pathological processes led to the investigation of the regulation of beta1,3-glucuronosyltransferase I (GlcAT-I), responsible for the completion of glycosaminoglycan-protein linkage tetrasaccharide, a key step prior to polymerization of chondroitin- and heparan-sulfate chains. We have cloned and functionally c...

Journal: :American journal of physiology. Endocrinology and metabolism 2006
David A Jacobson Julie Cho Luis R Landa Natalia A Tamarina Michael W Roe Joseph D Buxbaum Louis H Philipson

Calcium-binding proteins regulate transcription and secretion of pancreatic islet hormones. Here, we demonstrate neuroendocrine expression of the calcium-binding downstream regulatory element antagonistic modulator (DREAM) and its role in glucose-dependent regulation of prodynorphin (PDN) expression. DREAM is distributed throughout beta- and alpha-cells in both the nucleus and cytoplasm. As DRE...

Journal: :Journal of the Institute of Science and Technology 2022

The calcium-dependent adhesion protein E-cadherin encoded by the Cdh1 gene is a member of large family conferring proper establishment adherens junction. expression critical and observed in epithelial cells. also essential for establishing pluripotent state embryonic stem transcriptional regulation has been focus research many years; early reports identified repressors since its downregulation ...

Journal: :Cardiovascular research 1997
F C Tanner D P Carr G J Nabel E G Nabel

OBJECTIVE The introduction of recombinant genes into endothelial cells provides a method to study specific gene products and their effect on cell function. In addition, endothelial cells can be used for implantation into vessels or prosthetic vascular grafts. Because transfection efficiencies in human endothelial cells have been low, it is important to develop improved gene transfer techniques....

Journal: :Neuron 2002
Zhengui Xia Daniel R. Storm

In this issue of Neuron, report the discovery of a new transcription factor, CaRF, that contributes to calcium stimulation of the BDNF gene through CaRE1, one of several calcium response elements found in the promoter of the BDNF gene. The CaRF/CaRE1 transcriptional pathway may control the expression of genes critical for activity-dependent, long-term changes in the central nervous system (CNS).

2009
Elizabeth Schroder Miranda Byse Jonathan Satin

Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. The guiding hypothesis of this study is that a carboxyl-terminal cleavage product of the cardiac L-type calcium channel (CaV1.2) autoregulates expression. First, we confirmed that the CaV1.2 C terminus (CCt) is cleaved in murine cardiac myocytes from mature and developing ventricle. Overexpression of ful...

Journal: :Circulation research 2009
Elizabeth Schroder Miranda Byse Jonathan Satin

Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. The guiding hypothesis of this study is that a carboxyl-terminal cleavage product of the cardiac L-type calcium channel (Ca(V)1.2) autoregulates expression. First, we confirmed that the Ca(V)1.2 C terminus (CCt) is cleaved in murine cardiac myocytes from mature and developing ventricle. Overexpression of...

Journal: :Cardiovascular research 2009
Amanda Kasneci Naomi M Kemeny-Suss Svetlana V Komarova Lorraine E Chalifour

AIMS The transcription factor early growth response-1 (Egr-1) is increased in models of cardiac pathology; however, it is unclear how Egr-1 impacts the heart. We sought to identify how Egr-1 regulates expression of proteins involved in cardiomyocyte calcium homeostasis. METHODS Protein expression was measured by immunoblotting in control cardiac differentiated H9c2 cells or in H9c2 cells over...

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