Calcium phosphate nanoparticles (nanoCaP) conjugated with cis-diamminedichloroplatinum (CDDP, cisplatin) were prepared through the electrostatic binding of an aquated species of cisplatin to the nanoCaP in a chloride-free solution. The agglomeration of the nanoCaP that typically occurs during synthesis of CaP was controlled through the addition of DARVAN 811 immediately after precipitation and ...

INEB – Instituto de Engenharia Biomédica, Lab. de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150 -180 Porto, Portugal, [email protected] Rensselaer Poly. Institute, Materials Science and Engineering Dep., Troy, NY, 12180-3590 USA, [email protected], [email protected] Universidade do Porto, Faculdade de Engenharia, Dep. de Engenharia Metalúrgica e Materiais, Rua Dr. Roberto Fria...

The efficient intracellular delivery of (bio)molecules into living cells remains a challenge in biomedicine. Many biomolecules and synthetic drugs are not able to cross the cell membrane, which is a problem if an intracellular mode of action is desired, for example, with a nuclear receptor. Calcium phosphate nanoparticles can serve as carriers for small and large biomolecules as well as for syn...

Current procedures for the detection and identification of bacterial infections are laborious, time-consuming, and require a high workload and well-equipped laboratories. Therefore the work presented herein developed a simple, fast, and low cost method for bacterial detection based on hydroxyapatite nanoparticles with a nutritive mixture and the fluorogenic substrate. Calcium phosphate ceramic ...

Calcium phosphate was encapsulated into mesoporous silica nanoparticles (MSN). The effect of pH on the structure and morphology MSN release calcium from investigated. Epoxy coatings with (3 wt%) non-encapsulated wt% 5 were formulated their anti-corrosive performance evaluated by open circuit potential (OCP) electrochemical impedance spectroscopy (EIS) techniques. Results showed that encapsulati...

calcium acetate is used as an oral phosphate binder to control hyperphosphatemia in patients with chronic renal failure. compared to calcium carbonate, control of hyperphosphatemia can be achieved at lower calcium administration with calcium acetate which likely reduces the risk of hypercalcemia. in this study, various formulations of calcium acetate tablets were prepared and their disintegrati...