Clostridium perfringens β-toxin (CPB) is a β-barrel pore-forming toxin and an essential virulence factor of C. perfringens type C strains, which cause fatal hemorrhagic enteritis in animals and humans. We have previously shown that CPB is bound to endothelial cells within the intestine of affected pigs and humans, and that CPB is highly toxic to primary porcine endothelial cells (pEC) in vitro....

Completing our reports concerning the reaction products from calcium halides and the amino acid proline, two different solids were found for the reaction of l- and dl-proline with CaI2. The enanti-opure amino acid yields the one-dimensional coordination polymer catena-poly[[aqua-μ3-l-proline-tetra-μ2-l-proline-dicalcium] tetra-iodide 1.7-hydrate], {[Ca2(C5H9NO2)5(H2O)]I4·1.7H2O} n , (1), with t...

The effects of goitrogens on the thyroid gland have been much studied and calcium is considered as a goitrogen in some cases. Since the level of calcium is high in drinking water of some cities of Khozestan province, the effects of high calcium intake on the function of thyroid gland is investigated in this study. For this purpose the concentration of thyroid hormones is measured in rats. The s...

The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes a cyclic adenosine monophosphate (cAMP)-dependent chloride channel located mainly at the apical membrane of epithelial cells. In myocytes of pulmonary arteries, numerous chloride channels have been identified and described, but not the CFTR. Thus the presence and function of the CFTR was investigated in rat intrapulmona...

The properties of dry collodion membranes previously described allow the prediction that cells of these membranes will concentrate solutes under certain conditions. Three such cases have been studied experimentally. 1. A membrane containing thiosulphate and immersed in a solution of iodine concentrates iodide ion. 2. A membrane containing sodium chromate and immersed in mercury chloride concent...

purpose: to design and manufacture iodine 125 radioactive plaques which can be used in patients with ocular melanoma, and to evaluate the efficacy of plaques in an animal model. methods: this prospective basic study was performed in collaboration with farabi hospital and tehran atomic energy agency. the iodide 125 plaques were designed and manufactured based on the collaborative ocular melanoma...

Glycerinated rabbit psoas fibers 5-19 days old were immersed in contracting solutions with and without varying concentrations of different sodium salts. Raising the pH of the solution in small steps identified a threshold pH above which the fibers rapidly developed maximum tension. In solutions with added chloride or acetate (O-O.15 M), threshold pH and maximum tension changed only slightly. In...

1. Fibrin clots prepared in the absence of calcium can be dissolved in solutions of lithium chloride and bromide and sodium bromide and iodide, as well as of guanidine hydrochloride and urea. These salts do not denature fibrinogen under the same conditions of concentration, temperature, and time. Sedimentation experiments on the fibrin solutions show in each case a single sharp peak with a sedi...