The involvement of elements in the pathological process of primary hypertension has been established. The serum levels of copper, iron, zinc, sodium, potassium and calcium were studied by atomic absorption spectrophotometery and flame photometry in hypertensive and normal subjects. Serum copper and zinc levels were increased in hypertensive patients (25.5% and 14.7% respectively) as compar...

Intact human erythrocytes can be readily loaded with calcium by incubation in hypersomotic media at alkaline pH. Erythrocyte calcium content increases from 15-20 to 120-150 nmol/g hemoglobin after incubation for 2 h at 20 degree C in a 400 mosmol/kg, pH 7.8 solution containing 100 mM sodium chloride, 90 mM tetramethylammonium chloride, 1 mM potassium chloride, and 10 mM calcium chloride. Calciu...

Ciliary ganglion neurons, half of which normally suffer developmental death in the embryo, will survive in culture in medium supplemented with depolarizing concentrations of potassium. It is not known how elevated potassium acts inside the cell to promote survival. We report here that depolarizing concentrations of extracellular potassium promote neuronal survival by causing a sustained increas...

atp-sensitive potassium (katp) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. there has been considerable interest in exploring katp channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. the purpose of this study was to synthesize 3,3,6,6-tet...

Background: The results of the studies on the effects of sodium on bone metabolism have been inconsistent. There is no definitive answer to the question of whether sodium restriction can be associated with a lower incidence of osteoporosis. What reinforces the necessity of designing this study is the lack of findings with the approach of examining the effects of sodium on bone in our country. ...

This study was designed to determine whether alpha-receptor-stimulated monovalent ionic fluxes in rat aorta required calcium, and, if so, whether both extracellular calcium and cellularly stored calcium are active. Calcium removal in the presence of 10 mM magnesium (to maintain membrane stability) inhibited the norepinephrine-stimulated increase in potassium-42 and chloride-36 efflux. However, ...