The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (UV) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D(2) is much less bioactive than vitamin D(3) in humans. Metabolic activation and inactivation of vitamin D are well characterized and result in a plethora of meta...

The vitamin D endocrine system is required for the transcriptional regulation of a myriad vertebrate genes including those involved in bone health, growth, nutrient metabolism and immunity. requirements salmonids are amongst highest any aquaculture species. With nuances, pre-vitamin cholecalciferol (D3) via calcifediol (25-OH-D3), to produce physiologically active hormone calcitriol (1,25-OH-D3...

Introduction The aim of this EUnetHTA (European Network for Health Technology Assessment) Rolling Collaborative Review on high dose vitamin D the treatment COVID-19 was to inform health policy at an early stage in life cycle therapies and monitor ongoing studies format a Living Document. Methods systematic literature search conducted Medline, Pubmed, medRxiv, bioRxiv, arXivso, Cochrane Study Re...