Abstract Background ?-catenin is an important unit of the Wnt/?-catenin signaling pathway, a conserved process involving several physiological activities, encompassing differentiation and cell proliferation, etc. The dysfunction or mutation in causing initiation advancement various neoplasm types, including colorectal cancer, breast etc., has been reported. Therefore, therapeutic target. Hence,...

The goal of this study was to determine whether extracts and isolated alkylamides from Echinacea purpurea would be useful for prevention of the inflammatory response that accompanies infections with H1N1 influenza A. Seventeen extracts and 4 alkylamides were tested for the ability to inhibit production of cytokines, chemokines, and PGE₂ from RAW 264.7 macrophage-like cells infected with the H1N...

The ability of 36 phenolic acids and their derivatives to inhibit acetyl- and butyrylcholinesterase was studied. The most efficient acetylcholine inhibitors were: carnosic acid = gentisic acid > 3-hydroxy-4-methoxycinnamic acid = ethyl ferulate = ethyl vanillate = nordihydroguaiaretic acid > ethyl 4-hydroxybenzoate = methyl ferulate. The order of effectiveness towards butyrylcholinesterase was:...

Adiantum capillus-veneris is important endangered fern species with several medicinal properties. In this study, the leaves samples were extracted and separated using reversed phase HPLC with DAD for carotenoids, chlorophylls and phenolic compounds. Separation of carotenoids and chlorophylls were carried out using a tertiary gradient system of water, MTBE and methanol-water, while a binary grad...

This is the first report to identify the presence of chicoric acid (cichoric acid; also known as dicaffeoyltartaric acid, which is a caffeic acid derivatizedwith tartaric acid) in basil leaves. Rosmarinic acid, chicoric acid and caftaric acid (in the order of most abundant to least; all derivatives of caffeic acid) were identified in fresh basil leaves. Rosmarinic acid was themain phenolic comp...

The removal of stems prior to maceration during red winemaking is generally associated with an improvement in wine quality. However, recent years, increased interest the use has been observed among winegrowers. Different advantages this practice have listed literature. In order better understand their role winemaking, ten grape varieties from different winegrowing regions Switzerland were studi...

Nowadays consumers and the food trade increasingly interested in the geographical origin quality of food products. Authentication origins of wine has become a more important task than ever The best determination of the region of origin is possible on the basis of the analytical profile of wine. made to find useful chemical markers, based on the analysis of individual phenolic antioxidants and t...

This study sought to carry out a screening of the polyphenols from the aerial parts of four samples of Ocimum basilicum. HPLC-MS method was used to investigate the presence of phenolic compounds in the studied samples; caftaric, cafeic, chlorogenic, p-coumaric acids and rutin were identified. The total polyphenolic content was determined by using the Folin-Ciocalteu reagent, the flavonoid and t...

A "novel" protocol is presented for easy and reliable estimation of soluble hydroxycinnamate levels in Cichorium intybus L. leaf tissue in large-scale experiments. Samples were standardized by punching 6 discs per leaf, and hydroxycinnamates were extracted by submerging the discs in 80% ethanol with 5% acetic acid for at least 48 h in the darkness at 4°C. Residual dry mass of the discs was used...