نتایج جستجو برای: cacna2d1
تعداد نتایج: 28 فیلتر نتایج به سال:
BACKGROUND Cardiac ion channelopathies are responsible for an ever-increasing number and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that consists of an ST-segment elevation in the right precordial ECG leads, a shorter-than-normal QT interval, and a history of sudden cardiac death. METHODS AND RESULTS Eighty-two consecutive probands with Brugada syndr...
BACKGROUND MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese Medicine. In light of the important role of miRNAs in hepatocellular carcinoma, we questioned whether the inhibitory effects of ESC on hepatocellular carcinoma (HCC) were asso...
BACKGROUND Bipolar disorder (BD) is a highly heritable disease. While genome-wide association (GWA) studies have identified several genetic risk factors for BD, few of these studies have investigated the genetic etiology of specific disease subtypes. In particular, BD is positively associated with eating dysregulation traits such as binge eating behavior (BE), yet the genetic risk factors under...
BACKGROUND Neuronal hyperexcitability is a crucial phenomenon underlying spontaneous and evoked pain. In invertebrate nociceptors, the S-type leak K(+) channel (analogous to TREK-1 in mammals) plays a critical role of in determining neuronal excitability following nerve injury. Few data are available on the role of leak K(2P) channels after peripheral axotomy in mammals. RESULTS Here we descr...
OBJECTIVES To evaluate the association between a KCNQ1 mutation, R259H, and short QT syndrome (SQTS) and to explore the electrophysiological mechanisms underlying their association. METHODS We performed genetic screening of SQTS genes in 25 probands and their family members (63 patients). We used direct sequencing to screen the exons and intron-exon boundaries of candidate genes that encode i...
In the great majority of cases the ECG pattern of early repolarization (ERP) is a benign phenomenon observed predominantly in teenagers, young adults, male athletes and the black race. The universally accepted criterion for its diagnosis is the presence, in at least two adjoining leads, of ≥ 1 mm or 0.1 mV ST segment elevation. In benign ERP reciprocal ST segment changes are possible only in le...
Fucose-R(1-2)-galactose [FucR(1-2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, andmemory. However, an understanding of their precise roles has been hampered by a lack of information regarding FucR(1-2)Gal glycoproteins. Here, we report the first proteomic studies of this plasticity-relevant epitope. We identify five classes of putati...
Topics Include: • Fundamental Mechanisms of Cardiac Regeneration • Signaling in Vascular Smooth Muscle and the Heart • Calcium Handling in Cardiac Muscle by gest on Sptem er 4, 2017 http://circhajournals.org/ D ow nladed from Emerging Concepts in Cardiovascular Biology I: Late-Breaking Basic Science Oral Abstracts C-kit–Positive Cardiac Progenitor Cells Contribute to the Development of the Mamm...
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