نتایج جستجو برای: cacna2d1

تعداد نتایج: 28  

Journal: :Circulation 2007
Charles Antzelevitch Guido D Pollevick Jonathan M Cordeiro Oscar Casis Michael C Sanguinetti Yoshiyasu Aizawa Alejandra Guerchicoff Ryan Pfeiffer Antonio Oliva Bernd Wollnik Philip Gelber Elias P Bonaros Elena Burashnikov Yuesheng Wu John D Sargent Stefan Schickel Ralf Oberheiden Atul Bhatia Li-Fern Hsu Michel Haïssaguerre Rainer Schimpf Martin Borggrefe Christian Wolpert

BACKGROUND Cardiac ion channelopathies are responsible for an ever-increasing number and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that consists of an ST-segment elevation in the right precordial ECG leads, a shorter-than-normal QT interval, and a history of sudden cardiac death. METHODS AND RESULTS Eighty-two consecutive probands with Brugada syndr...

2018
Xiaoni Liu Shuang Wang Jianji Xu Buxin Kou Dexi Chen Yajie Wang Xiaoxin Zhu

BACKGROUND MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese Medicine. In light of the important role of miRNAs in hepatocellular carcinoma, we questioned whether the inhibitory effects of ESC on hepatocellular carcinoma (HCC) were asso...

Journal: :Journal of affective disorders 2014
Stacey J Winham Alfredo B Cuellar-Barboza Susan L McElroy Alfredo Oliveros Scott Crow Colin L Colby Doo-Sup Choi Mohit Chauhan Mark A Frye Joanna M Biernacka

BACKGROUND Bipolar disorder (BD) is a highly heritable disease. While genome-wide association (GWA) studies have identified several genetic risk factors for BD, few of these studies have investigated the genetic etiology of specific disease subtypes. In particular, BD is positively associated with eating dysregulation traits such as binge eating behavior (BE), yet the genetic risk factors under...

2011
Astrid Tulleuda Barbara Cokic Gerard Callejo Barbara Saiani Jordi Serra Xavier Gasull

BACKGROUND Neuronal hyperexcitability is a crucial phenomenon underlying spontaneous and evoked pain. In invertebrate nociceptors, the S-type leak K(+) channel (analogous to TREK-1 in mammals) plays a critical role of in determining neuronal excitability following nerve injury. Few data are available on the role of leak K(2P) channels after peripheral axotomy in mammals. RESULTS Here we descr...

2015
Zhi-Juan Wu Yun Huang Yi-Cheng Fu Xiao-Jing Zhao Chao Zhu Yu Zhang Bin Xu Qing-Lei Zhu Yang Li

OBJECTIVES To evaluate the association between a KCNQ1 mutation, R259H, and short QT syndrome (SQTS) and to explore the electrophysiological mechanisms underlying their association. METHODS We performed genetic screening of SQTS genes in 25 probands and their family members (63 patients). We used direct sequencing to screen the exons and intron-exon boundaries of candidate genes that encode i...

Journal: :Cardiology journal 2012
Andrés Ricardo Pérez-Riera Luiz Carlos de Abreu Frank Yanowitz Raimundo Barbosa Barros Francisco Femenía William F McIntyre Adrian Baranchuk

In the great majority of cases the ECG pattern of early repolarization (ERP) is a benign phenomenon observed predominantly in teenagers, young adults, male athletes and the black race. The universally accepted criterion for its diagnosis is the presence, in at least two adjoining leads, of ≥ 1 mm or 0.1 mV ST segment elevation. In benign ERP reciprocal ST segment changes are possible only in le...

2009
Heather E. Murrey Scott B. Ficarro Chithra Krishnamurthy Steven E. Domino Eric C. Peters Linda C. Hsieh-Wilson

Fucose-R(1-2)-galactose [FucR(1-2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, andmemory. However, an understanding of their precise roles has been hampered by a lack of information regarding FucR(1-2)Gal glycoproteins. Here, we report the first proteomic studies of this plasticity-relevant epitope. We identify five classes of putati...

2006
Grazia Iaffaldano

Topics Include: • Fundamental Mechanisms of Cardiac Regeneration • Signaling in Vascular Smooth Muscle and the Heart • Calcium Handling in Cardiac Muscle by gest on Sptem er 4, 2017 http://circhajournals.org/ D ow nladed from Emerging Concepts in Cardiovascular Biology I: Late-Breaking Basic Science Oral Abstracts C-kit–Positive Cardiac Progenitor Cells Contribute to the Development of the Mamm...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید