The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used Gram-negative bacteria (Pseudomonas aeruginosa and Proteu...

Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used Gram-negative bacteria (Pseudomonas aeruginosa and Proteus mirabilis) that were genetically engineered to be bioluminescent, which allowed for noninvasive, sequential optical i...

The aim of this study was to prevent eschar formation in thermally injured patients during the use of povidoneiodine ointment by modifying therapeutic protocols depending on normal events in healing process. Sixty thermally injured patients of different age groups, sex, and occupation with different burn sizes were involved in the study, allocated to two groups. Group A was made up of 17 patien...

Figure 1. Full thickness electrical burn to the first web space of the left hand showing exposed tendons. DESCRIPTION A 34-year-old right-hand-dominant man sustained an electrical injury to his left hand while handling a 450-volt cable. He presented with deep burns to the first web space and the dorsal aspect of the index finger. The excision of the eschar resulted in exposure of bare tendons (...

Definitions It is very important for the clinician caring for a burn victim to know the depth, or degree, of burn. A first-degree burn is superficial, dry, painful to touch, and heals in less than 1 week. A second-degree burn is partial thickness and pink or possibly mottled red. It exhibits bullae or frank weeping on the surface. It usually is painful unless classified as deep and heals in 1 t...

OBJECTIVE To determine if local prophylactic application of probiotic bacteria to burn wounds will prevent death in a mouse model of burn wound sepsis. BACKGROUND Infection remains the most common complication after burn injury and can result in sepsis and death, despite the use of topical and systemic antibiotics. Pseudomonas aeruginosa is a frequently implicated pathogen. Local application ...

Burn injury is debilitating and among one of the most frequently occurring traumas. Critical care improvements have allowed for increasingly positive outcomes. However, infection, whether it be localized to site wound or systemic in nature, remains a serious cause morbidity mortality. Immune suppression predisposes burn population development invasive infections; this along with possibility inh...

BACKGROUND The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion and proliferation of P. aeruginosa within the burn wound and reduce mortality. METHODS Thermal injuries were induced in anesthetized mice, and P. aeruginosa was applied to th...

Background: Full-thickness burn injuries (FTBI) not only lead to a significant burden in multiple ways, including social life and self-esteem, but have also tremendous impact on environmental interaction by reducing sensibility manifold ways. On these grounds, possible ways solutions recover wounds are essentials should be overlooked. Methods: A review of experimental, clinical studies the rela...