Introduction: Burkitt lymphoma (BL) is rare, but an aggressive malignancy. Central nervous system Burkitt lymphoma (CNSBL) is very rare. CNS Burkitt’s lymphoma is treated with high-dose chemotherapy and radiation. Radiotherapy in children younger than three years old may cause major CNS damage. Case report: A three-year-old boy presented with painful proptosis of the left eye. He underwent aden...

Pediatric Burkitt lymphoma is a malignant high grade mature B-cells non-Hodgkin lymphoma, whose prognosis has radically improved thanks to advances in chemotherapy. Hence the need for early diagnosis and treatment. Our study is a report on observations of pediatric Burkitt lymphoma revealed by acute intussusception emphasizing the importance of evoking a diagnosis in front of unusual signs of d...

Burkitt lymphoma is a germinal center B-cell-derived cancer that was instrumental in the identification of MYC as an important human oncogene more than three decades ago. Recently, new genomics technologies have uncovered several additional oncogenic mechanisms that cooperate with MYC to create this highly aggressive cancer. The transcription factor TCF-3 is central to Burkitt lymphoma pathogen...

Primary central nervous system Burkitt lymphoma (PCNSBL) is rare. Few cases of primary central nervous system involvement with sporadic Burkitt lymphoma have been reported and its treatment is now controversial. Here, the authors report a case of a 14-year-old boy suffering from non-immunoglobulin heavy chain (IgH) translocation PCNSBL. To the authors' knowledge, this is the second case report ...

A recent population-based study on 2000 adult patients with Burkitt lymphoma presented a novel score that takes into account age, race and clinical stage to prognosticate survival. The outcome of patients with Burkitt lymphoma has improved in the last decade, likely due to intensive chemotherapy regimens and anti-CD20 monoclonal antibody therapy. There is, however, a lack of improvement in the ...

Primary pancreatic lymphoma (PPL) is of very rare occurrence as an extra nodal site of Non-Hodgkin's lymphoma (NHL). It represents less than 1% of NHL. Out of which Burkitt lymphoma of pancreas is of a rare presentation. It usually occurs in children and presenting in adults is uncommon. The prevalence of pancreatic Burkitt lymphoma is not known as the incidence is significantly low. Clinical f...

A monoclonal antibody, referred to as 38.13, was obtained by fusing murine myeloma cells with Lewis rat splenocytes sensitized with Daudi cells (human Burkitt lymphoma containing Epstein--Barr virus genome but lacking HLA-A, -B, and -C and beta 2-microglobulin molecules at the cell surface). 38.13 antibody was demonstrated to be a rat IgM. By complement-dependent microcytotoxicity and indirect ...

Burkitt lymphoma is a cancer of the lymphatic system (in particular, B lymphocytes). It was named after Denis Parson Burkitt, a missionary doctor/surgeon and a research scientist, who first described the disease in 1958 while working in Equatorial Africa. In the original report, this type of lymphoma was described in the jaw of young African children. Dennis Burkitt was born in Ireland February...

BACKGROUND Recent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this is reflected by the presence of lipid droplets which are visible in the cytoplasm of neoplastic cells in cytological preparations. These vacuoles are not identifiable in biopsy section as lipids are "lost" during tissue processing. METHODS AND RESULTS In this study we investigated...