Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detected with d...

The Gulf Journal of Dermatology and Venereology ABSTRACT Psoriasis vulgaris and bullous pemphigoid represent two clinically well-characterized, chronic, inflammatory skin diseases. The concomitant occurrence of these two entities in a patient is rare, and the exact nature of this relationship is not clear. We describe a 31-year-old woman with a history of plaque-type psoriasis who presented wit...

Bullous pemphigoid is the most common autoimmune blistering disease in industrialized countries and particularly affects elderly. In this patient population, comorbid diseases are frequent may complicate management treatment of bullous pemphigoid. A better understanding why distinct more patients lead to new pathophysiological insights - as a consequence result care. The association with neurol...

BACKGROUND Human amnion membrane (HAM) was suggested to be a superior antigenic substrate for immunoblotting in detecting autoantibodies of autoimmune bullous skin diseases. OBJECTIVES To determine the properties of HAM as an antigenic substrate for the detection of autoantibodies in pemphigus vulgaris and bullous pemphigoid. METHODS Immunomapping and tandem liquid chromatography mass spect...

Linear IgA disease (LAD) is a chronic, acquired, autoimmune bullous disease. Generalized bullous eruptions is not unusual in the intensive care unit. The cause can be idiopathic, autoimmune, or drug induced but prompt recognition is crucial to their management. The autoimmune blistering skin diseases are a heterogeneous group of diseases associated with autoantibodies that are directed against ...

Background: Pemphigus diseases including pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoimmune diseases that cause severe blistering of the skin and mucous membranes. Among inflammatory mediators, reactive oxygen species (ROS) are involved in the pathogenesis of a wide variety of diseases through oxidative stress for which protein carbonyl (PC) and total antioxidant capacity (TAC) ...

Background: Bullous diseases are classified as autoimmune blistering diseases, hereditary disorders, and secondary to inflammation physical trauma. This study evaluated clinicopathological features of patients with bullous diseases. Methods: is a retrospective cross-sectional 88 vesiculobullous referred the dermatology clinic Afzalipour hospital in Kerman, Iran. Demographic patients, type lesio...

Pemphigoid diseases (including bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA dermatosis, lichen planus pemphigoides, and anti-p200 pemphigoid) are a subgroup of autoimmune bullous skin diseases characterized by an autoantibody response toward structural components of the hemidesmosome resulting in subepidermal blistering. By the use of different in vitro sys...

Animal models of human diseases are very useful to better understand their pathomechanism and to develop new therapies. However, due to the differences among different species, it is sometimes difficult to reproduce reliable diseases phenotype in animals. Bullous pemphigoid is the most common autoimmune blistering skin disease, in which circulating IgG autoantibodies directed against type XVII ...