Cellular activity of the tumor suppressor protein p53 is primarily regulated by posttranslational modifications. Phosphorylation of the COOH terminus, including Ser389, is thought to result in a conformational change of the p53 protein, enhancing DNA binding and transcriptional activity. In vitro studies presented here show that, in addition to UV radiation, Ser389 is phosphorylated upon exposu...

background: tumors involving the hand skeleton are rare. however, a basic knowledge of hand tumors is necessary for every clinician. this is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. methods: this study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, imam khomeini hospital in tehr...

Tumor lysis syndrome is a potentially fatal complication of anti-cancer therapy that is usually seen in patients with bulky, rapidly proliferating, treatment-sensitive tumors such as hematological malignancies, but it rarely occurs in a variety of solid tumors such as colorectal carcinoma. Combination chemotherapy with infusional 5-fluorouracil/leucoverin and irinotecan has been recently accept...

OBJECTIVE To comprehensively analyze the spectrum of imaging features of the primary tumors and metastatic patterns of the Extraskeletal Ewing sarcoma family of tumors (EES) in adults. MATERIALS AND METHODS We performed a computerized search of our hospital's data-warehouse from 1996 to 2013 using codes for Ewing sarcoma and primitive neuroectodermal tumors as well as the demographic code for...

Metastatic cold tumors with a large primary site (i.e., >5 cm) represent an open issue as surgery is often excluded and immunotherapy (IT) have reported limited response, because of the immunosuppression present in their microenvironments (cold TME).

In order to increase the diagnostic value of ultrasound diagnostics, qualitative and quantitative Doppler indicators in detection bulky ovarian tumors were determined. A comprehensive examination 149 patients with additional tumors, which consisted three groups patients. The control group included 30 women who did not have large tumors. Detailed assessment blood flow loci was determined using e...

Patients with advanced disseminated germ cell tumors of the testis, retroperitoneum, and mediastinum have impaired survival compared to other patients with disseminated germ cell tumors having less bulky metastatic disease. Among patients with advanced disseminated germ cell tumors, we currently lack adequate predictors of long-term survival. Flow cytometric analysis of the paraffin-embedded, f...

BACKGROUND Adult hemangiomas are rare, slowly progressing vascular tumors. Potential complications include laryngeal involvement or massive tumor burden. METHODS A case of recurrent, bulky laryngeal hemangioma involving the parapharyngeal space is presented herein. The clinical course and treatment are described, and a series of MRI studies are compared to demonstrate the treatment response. ...