The Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has been approved for the treatment of chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's macroglobulinemia. Acquired resistance to ibrutinib due to BTK C481S mutation has been reported. Mutations in PLCγ2 can also mediate resistance to ibrutinib. Untoward effects due to off-target effects are also disadvantages of ibruti...

Available online xxxx Field Editor: Garry Bruton ucts and services, howcan institutions remain unchanged? This paper explores this theoretical conundrum empirically through the examination of the actions of entrepreneur Lowell Wakefield. If entrepreneurs are constrained and shaped by existing institutions, how? If entrepreneurs prodContrary to previous work that suggests that it is institutiona...

[PDF] [Full Text] , December , 2011; 45 (15): 1246-1248. Br J Sports Med Linda M Castell Andrew M Jones, Satoshi Haramizu, Mayur Ranchordas, Louise Burke, Samantha Stear and Part 27 −− aids for health and performance Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic − A [PDF] [Full Text] [Abstract] , August 1, 2012; 590 (15): 3575-3583. J Physiol O. Lund...