communities. Many communities and tribal governments have established research and ethics review boards to evaluate proposed projects in their communities, stemming from a growing awareness and sophistication of issues surrounding genetic and biomedical research, including individual versus community (or cultural) risk, adequacy of individual versus community consent issues, confidentiality, re...

• Then we could implement a model human, which, given input data comparable to what a human child gets, would acquire morphology and morphophonemics. It would generate new members of paradigms: “if [glEmp] is a verb, its past tense must be [glEmpt]” It would produce multiple responses and ambivalent judgments where people do: “past of [splIN] could be [spl√N], or [splINd], or perhaps even [splæ...

BRUCE is implicated in the regulation of DNA double-strand break response to preserve genome stability. It acts as a scaffold to tether USP8 and BRIT1, together they form a nuclear BRUCE-USP8-BRIT1 complex, where BRUCE holds K63-ubiquitinated BRIT1 from access to DSB in unstressed cells. Following DSB induction, BRUCE promotes USP8 mediated deubiquitination of BRIT1, a prerequisite for BRIT1 to...

Computer he most important recorded information medium on the Internet, and in the world at large, is the document. Although text might seem prosaic in contrast to multimedia objects, it is still the major medium for communicating information. Internet document retrieval can draw upon years of research results and practical experience in on-line information access as well as from traditional ph...

al contours of American social inequality have been transformed by the rapid growth in the prison and jail population.1 America’s prisons and jails have produced a new social group, a group of social outcasts who are joined by the shared experience of incarceration, crime, poverty, racial minority, and low education. As an outcast group, the men and women in our penal institutions have little a...

LIPN, UMR CNRS 7030. Institut Galilée Université Paris-Nord, 99, avenue Jean-Baptiste Clément 93430 Villetaneuse, France. 2 Université Pierre et Marie Curie, Laboratoire de Physique Théorique de la Matière Condensée, CNRS UMR 7600 Tour 16, 2 étage, 4, place Jussieu, F 75252 Paris Cedex 05, France. 3 H. Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences Division of Theoreti...

Degradation of certain inhibitor of apoptosis proteins (IAPs) appears to be critical in the initiation of apoptosis, but the factors that regulate their degradation in mammalian cells are unknown. Nrdp1/FLRF is a RING finger-containing ubiquitin ligase that catalyzes degradation of the EGF receptor family member, ErbB3. We show here that Nrdp1 associates with BRUCE/apollon, a 530 kDa membrane-a...

These are notes on Perelman’s papers “The Entropy Formula for the Ricci Flow and its Geometric Applications” [51] and “Ricci Flow with Surgery on Three-Manifolds’ [52]. In these two remarkable preprints, which were posted on the ArXiv in 2002 and 2003, Grisha Perelman announced a proof of the Poincaré Conjecture, and more generally Thurston’s Geometrization Conjecture, using the Ricci flow appr...